C. Wang

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

A meta-analysis of Microarray Data is Effective for Identifying Gravity-Sensitive Genes

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

High resolution ultrasonic neural modulation observedvia in vivo two-photon calcium imaging

This study develops a dual-modality system to investigate high-frequency ultrasound's effect on neuronal activity in awake mice, achieving 100-micron spatial resolution.

The radish Ogura fertility restorer impedes translation elongation along its cognate CMS-causing mRNA

The paper shows that the Ogura CMS fertility restorer Rfo inhibits translation of the CMS-causing mRNA orf138 by blocking ribosome elongation.

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

AIM-CICs: automatic identification method for Cell-in-cell structures based on convolutional neural network

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

The Diameter Factor of Aligned Electrospinning Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization

This study shows that aligned electrospinning membranes with 319 nm diameter enhance skin wound healing by promoting epithelialization and macrophage transformation through IL10 and TGFβ expression.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

This study identifies a unique GCN5 histone acetyltransferase complex in Plasmodium falciparum that regulates erythrocyte invasion and virulence by modulating chromatin states and gene expression.

Synergistic Therapy of Doxorubicin with Cationic Anticancer Peptide L-K6 Reverses Multidrug Resistance in Cancer Cells in vitro via P-glycoprotein Inhibition

This study shows that the cationic peptide L-K6 enhances doxorubicin's effectiveness in drug-resistant cancer cells by inhibiting P-glycoprotein function and expression.

LncRNA XIST knockdown suppresses cell proliferation and promotes apoptosis in diabetic cataract via miR-34a/SMAD2 axis

This study shows that XIST knockdown reduces cell proliferation and increases apoptosis in diabetic cataract by regulating the miR-34a/SMAD2 axis.

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

FOD-Net: A Deep Learning Method for Fiber Orientation Distribution Angular Super Resolution

FOD-Net improves angular resolution of FOD images from clinical dMRI data to match research-quality data, enabling better tractography and connectome reconstruction.

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-cell Growth and Survival

This study investigates the role of CTPS1 and CTPS2 in EBV-infected B-cells, showing their importance in cell growth and survival, and suggests they are potential therapeutic targets.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

C1q/CTRP1 exerts neuroprotective effects in TBI rats by regulating inflammation and autophagy

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

Structural basis for broad coronavirus neutralization

This study identifies a monoclonal antibody that broadly neutralizes multiple beta-coronaviruses by targeting a conserved epitope, providing a structural basis for designing pan-coronavirus vaccines.

Hsp70 chaperons TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

Sugarcane Nitrogen and Irrigation Level Prediction Based on UAV-Captured Multispectral Image at Elongation Stage

This paper uses UAV-captured multispectral images to predict sugarcane canopy nitrogen content and irrigation levels using PLS, BPNN, ELM, and SVM models.

Isothermal Amplification of Nucleic Acids with Ladder-shape Melting Curve

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

Collagen induced inflammations

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

Role and Dynamics of Vacuolar pH during Cell-in-Cell mediated Death

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

Music for cells? A systematic review of studies investigating the effects of audible sound played through speaker-based systems to cell cultures.

This review examines 12 studies on the effects of audible sound on cell cultures, finding varied outcomes like enhanced migration and differentiation but noting methodological inconsistencies.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.