C. Xu

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

This study identifies the mitochondrial RNA granule as a protective mechanism against manganese toxicity by showing its downregulation enhances cell survival.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper investigates how compensation between paralogs evolves in plant stem cell control, showing that a single amino acid change and cis-regulatory variation can reduce compensatory ability in tomato.

This paper develops a cryoET processing pipeline using CNNs to characterize the morphology and structure of influenza viruses, improving analysis throughput and enabling subtomogram averaging of glycoproteins.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

The paper develops a process-based mosquito population model that improves yearly population predictions by integrating temperature, water, and lab-derived data.

This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

MONTE enables serial multi-omic analysis of immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome from the same tissue samples, preserving precious human material and identifying immunotherapeutic targets.

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

The paper shows that SLs in SRPS operons of Clostridium spp. evolve with specific selection pressures, revealing a link between operon stoichiometry and evolution.

The paper identifies enhancer heterogeneity in gastric cancer by integrating epigenomic data and functional assays, linking it to genetic and regulatory factors.

This study investigates how two first-generation MsbA inhibitors, TBT1 and G247, induce opposite allosteric effects by binding to distinct sites in the transmembrane domains.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper develops activity-based probes to analyze KLK activome dynamics in prostate cancer, revealing KLK14's role in migration and secretion into the bone microenvironment.

This study determines the cryo-EM structures of LolCDE and reveals its mechanism for extracting triacylated lipoproteins from the cytoplasmic membrane.

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

This study identifies TFAM3 as a regulator of shoot meristem maturation in plants, showing that ALOG family proteins form transcriptional condensates to control flowering timing and inflorescence architecture.

FastTomo is a SerialEM script that improves electron tomography data collection speed by minimizing off-target tracking shots and using proportional control.

The paper identifies cellular flow avalanches in a Drosophila eye disc model, showing they regulate tissue growth and follow a power law distribution.

The paper examines gene x environment interactions in PTSD by analyzing glucocorticoid-induced transcriptomics in human neurons and blood cells from veterans with and without PTSD.