C. Xu

This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study shows SMARCAL1 loss-of-function mutations enable ALT in telomerase-negative glioblastoma cells, promoting tumorigenesis and telomere maintenance.

The paper demonstrates that fibroblast subtypes differ in FAP tracer internalization rates, enabling imaging of inflammation resolution in joints.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

This study identifies a growth-related gene in Arabidopsis thaliana associated with reduced aphid abundance through delayed growth and flowering.

The paper identifies UBR5 as a quality control enzyme that degrades unpaired transcription factor subunits, shaping network dynamics and gene expression through continuous turnover.

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

This paper identifies HY-008, a PDGFRα inhibitor with high BBB permeability, as effective against glioblastoma in vitro and in vivo, showing improved survival and synergy with TMZ.

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

The paper introduces a method to detect frequency-dependent selection by analyzing genotype similarity's effect on fitness components using regression analysis in Arabidopsis and damselfly data.

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

This paper quantifies the human cost of global warming by estimating how many people will be outside the historical climate niche under different warming scenarios.

The paper identifies miRNA targets in maize using PARE datasets, revealing tissue-specific cleavage and new miRNA-target pairs involved in seed germination.

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.