C. Xu

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

This study examines how meteorological factors affect wheat irrigation water requirements in the Beijing-Tianjin-Hebei region from 2000 to 2019, showing trends and correlations with climate variables.

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

This paper develops INSIGHT, a mass-barcoded peptide sensor for noninvasive monitoring of checkpoint blockade therapy response and resistance in mice.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

This study evaluates the antiviral effects of mouth rinses on SARS-CoV-2 infectivity in vitro, finding that some products significantly reduce viral infectivity while others cause cytotoxicity.

This study shows mucosal vaccination with CDN adjuvants induces T cells that home to lungs and provide IL-17-dependent protection against M. tuberculosis.

The paper investigates how the valency of F-domain scaffolds affects signaling through the angiopoietin pathway, finding that higher valency mimics Ang1's pro-angiogenic effects while lower valency mimics Ang2's antagonistic effects.

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

The paper examines mRNA expression patterns across nine species to assess the applicability of Haeckel's postulates, finding partial conservation and alignment with terminal edition patterns.

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

The paper shows that specific small RNAs inhibit androgen signaling and induce cell death in prostate cancer cells by targeting AR-coregulatory genes through 3-UTR complementarity.

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

The paper reports the cryo-EM structure of native human uromodulin, revealing its filamentous conformation and mechanism of bacterial binding.

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This paper develops a sensitive and reusable method for detecting Exo III activity using DNB nanoarrays and cPAS sequencing technology, showing a linear response in low concentration ranges.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study identifies Rv3194c as a hyaluronic acid-binding adhesin in Mycobacterium tuberculosis that facilitates lung epithelial interaction, with its binding site P91-110 serving as a potential therapeutic target.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

This study shows Bmal1 integrates mitochondrial metabolism and macrophage activation, with implications for immunotherapy and inflammatory diseases.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.