G. Wu

This study shows that cyt b5 reductase, cyt b5, and SCD1 form a stable ternary complex mediated by transmembrane helices, enhancing electron transfer rates.

This paper constructs a prognostic model for clear cell renal cell carcinoma using immune cell-related genes from single-cell RNA-seq and transcriptome data, validated with clinical outcomes.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

The paper evaluates lectins for anti-rabies virus activity, identifies Urtica dioica Agglutinin (UDA) as effective in preventing RABV infection in a muscle explant model.

This study shows that simultaneous knockout of Tgfbr1 and Acvr1b in muscle leads to hypertrophy and enhanced regeneration, but not when only one receptor is knocked out.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

This study uses cryo-EM to determine the structure of the TSCC complex, revealing its architecture and potential mechanisms of Rheb regulation.

This study shows DDX5 resolves a G-quadruplex in STAT1 mRNA 5UTR, enabling STAT1 translation and interferon signaling in HBV-infected hepatocytes.

This study examines how energy substances, reactive oxygen species, enzyme activities, and endogenous hormones influence somatic embryogenesis and abnormal callus formation in Ormosia henryi Prain.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

The paper investigates how Siglec-1 binding to activated regulatory T cells changes with glycosylation and identifies potential Siglec-1 counter-receptors.

The paper identifies genome-wide roles of the Integrator complex in attenuating non-productive transcription by dampening weak promoters and quality-controlling RNAPII complexes.

This study identifies a cross-regulation mechanism between RpfG and HtsH1/HtsH2/HtsH3 proteins in Lysobacter that controls antibiotic biosynthesis without requiring RpfG's phosphodiesterase activity.

This study identifies CD11c+CD88+CD317+ myeloid cells as key drivers of CNS autoimmunity and shows that targeting these cells with anti-CD317 mAb reduces disease.

This study compares antioxidant enzyme activity, dehydrin expression, and gene expression in two switchgrass cultivars under drought stress to identify markers of drought tolerance.

This study shows that intermittent hypoxia in mice alters gene expression in lung cells, particularly in endothelial cells, linking it to pulmonary fibrosis and hypertension pathways.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

This study shows that blue light sensed by OPN3 in adipocytes regulates thermogenesis and lipolysis in mice.

The paper reports the crystal structure and cryo-EM reconstruction of a constitutively active Drosophila Orai mutant, revealing the molecular mechanism of channel activation and Ca2+ permeation.

The paper identifies gene acquisitions in Xanthomonas vasicola pv. vasculorum genomes from the U.S. and Argentina, linking them to increased virulence through horizontal gene transfer, including a prophage from X. vasicola pv. holcicola.

The paper uses direct fluorescent glycan labeling to image N- and O-glycans on HeLa cells, revealing distinct distribution patterns of Core-1 O-glycans, N-glycans, and sialyl T antigen.

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.