J. Liu

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This paper introduces a self-immolative linker that restores activity to an inactive heparanase probe, enabling facile development of activatable imaging probes.

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

This study develops a versatile linker chemistry for in situ labeling of hydrolase-targeting probes using quinone methide species, showing improved labeling efficiency in living cells.

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

This paper introduces a temperature-inducible pgSIT method in Drosophila that eliminates the need for genetic crosses and sex sorting to produce sterile males for population control.

The paper introduces a single-cell cyclic multiplex in situ tagging (CycMIST) technology to comprehensively profile functional proteins in single neurons, demonstrating its ability to detect 182 proteins in a neuron cell line and reveal differential expression in an Alzheimer's disease model.

The paper investigates the composition and biophysical properties of the Spa33 heterotrimers in the Shigella T3SS sorting platform, proposing a model for their structure and function.

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

This study examines the correlation between vaccine-induced IgG levels and neutralizing titers against SARS-CoV-2 and its variants, finding a significant positive correlation and reduced neutralization against variants.

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This study uses urinary metabolomics in a rat model to show that taurine levels increase on day 1 of polymyxin B treatment and correlate with kidney injury markers.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This paper identifies selenok's self-cleavage activity and its specific interaction sites, suggesting a regulatory role in its protein interactions and cellular functions.

This study evaluates fitness costs of CRISPR/Cas9 in Drosophila by tracking allele frequencies of transgenic constructs, finding moderate off-target costs but no direct Cas9 costs, with Cas9HF1 minimizing off-target effects.

This study identifies ABCG17 and ABCG18 as ABA importers that redundantly regulate ABA homeostasis and translocation in Arabidopsis, affecting stomatal closure and root development.

This paper evaluates a SARS-CoV-2 mRNA vaccine, PTX-COVID19-B, showing it is safe, effective, and induces strong immune responses in mice and hamsters, with ongoing human clinical trials.

This paper introduces a general finite-element framework for the Virtual Fields Method to identify constitutive parameters in nonlinear elasticity using measured deformation fields.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study compares aerosol and intranasal SARS-CoV-2 exposure in macaques, finding aerosol exposure in cynomolgus macaques causes more severe disease than other models.

The paper links vancomycin toxicity data from a rat model to two human clinical studies, showing rats are more sensitive to kidney injury at therapeutic concentrations.

The paper measures efficient Forster resonance energy transfer from quantum dots to bacterial reaction centers in nanoconjugates, showing a 26.6 ns time scale and 0.75 efficiency.

This study examines how combining straw returning with potassium fertilizer affects spring maize's lodging resistance, grain quality, and yield in Inner Mongolia.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

This study examines how potassium fertilizer affects dry matter accumulation and potassium absorption in maize inbred lines with different yield types over three years.