K. Li

This paper develops a mass spectrometry method to detect microproteins in vaginal lavages and identifies cystatin A as a potential biomarker for early ovarian cancer detection.

Cryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences.

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

This paper introduces SHARC, a method to measure RNA 3D distances and alternative conformations in cells, revealing RNA structures and improving 3D modeling.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

The paper describes methods to produce pure, active mixed isotopically labeled dimer of chorismate mutase using CuAAC for structural studies of allostery.

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

This study models how MUC1 affects influenza virus infection and macrophage dynamics, finding it reduces viral reproduction and macrophage recruitment but not viral load.

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

The paper identifies structurally similar protease inhibitors for TMPRSS2, showing Avoralstat reduces SARS-CoV-2 infection in mice.

This study investigates the genetic and physical interactions between SQUAMOSA and SVP MADS-box proteins in wheat spike development, showing their roles in regulating meristem transitions and floral development.

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

This study identifies three evolutionary genetic routes of Pseudomonas aeruginosa adaptation in the sinuses of people with cystic fibrosis, suggesting sinuses may be an early site of pathoadaptation before lung infections.

This study uses single-cell RNA sequencing to identify distinct MAIT cell subtypes with different functional states during activation and infection.

The paper tests hypotheses about genetic diversity patterns in Betula albosinensis, finding support for the central-marginal hypothesis and the role of multiple glacial refugia.

This study shows that priming MAIT cells in mice with 5-OP-RU and P2C increases their activation and expansion but does not improve control of Mtb infection.

This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.

This study identifies a cross-regulation mechanism between RpfG and HtsH1/HtsH2/HtsH3 proteins in Lysobacter that controls antibiotic biosynthesis without requiring RpfG's phosphodiesterase activity.

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

This study uses microscopy techniques to reveal the structural features of the septum in Staphylococcus warneri, showing it is composed of two layers with concentric peptidoglycan rings.

The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.

This study develops a mathematical model to explore the relationship between macrophage activation and viral shedding in influenza infection, revealing that macrophage depletion drives the negative correlation between activation and viral shedding.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

This study investigates how loop extrusion factors and chromatin structure influence chromatin dynamics using microscopy, genetics, and simulations in fission yeast.