K. Li

This study identifies leafhoppers as vectors for SoSGV, a virus associated with soybean stay-green syndrome, and shows they can transmit the virus to legume plants.

This paper develops an antibody-drug conjugate targeting Pseudomonas aeruginosa that kills bacteria with minimal mammalian cell toxicity and synergizes with antibiotics.

This paper develops a method for analyzing bivalent analyte binding kinetics in high-throughput SPR data, improving parameter estimation and identifiability through grid search and profile likelihood analysis.

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

This paper uses integrated PET and confocal imaging to establish a spatiotemporal timeline for vascular reconnection during grafting in tomato.

This study compares the effects of Physiologix XF SR and fetal bovine serum on MAIT cell expansion, finding that Phx enhances proliferative capacity and functional responses.

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

This study identifies Neu1 as a therapeutic target for coronavirus infection by showing its role in sialylation of viral proteins and demonstrates that a Neu1 inhibitor reduces viral replication in vitro and in vivo.

This study investigates the therapeutic effect of NF-κB decoy ODN-loaded PLGA nanospheres in reducing alveolar ridge resorption after tooth extraction in rats.

This study introduces a matrix completion method to predict chemical-target interactions, achieving high accuracy and demonstrating its utility for prioritizing environmental chemicals.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study develops a mathematical model to analyze viral dynamics in HP and LP influenza infections, finding HP viruses have higher infection rates and lower interferon production, leading to more severe tissue damage.

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

The paper compares the effects of local and landscape-scale factors on seasonal bee communities to guide land management practices.

The paper shows that aging-related iron accumulation reduces estrogen receptor expression, diminishing the benefits of hormone replacement therapy in late postmenopausal women with atherosclerosis.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

This study uses a VAE to map fMRI data into a latent space, enabling the modeling of transient co-activity patterns and their temporal dynamics.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

CHA1, a combination of EGCG and decitabine, reprograms TNBC tumors and their microenvironment by inhibiting Wnt and activating JAK/STAT/IFN signaling, enhancing PD-L1 expression and T-cell infiltration.

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

This paper introduces a synthetic carbon fixation cycle in plants that fixes CO2 without RuBisCO, showing increased photosynthetic capacity in transgenic Camelina sativa.

This study creates a genome-wide atlas of antibiotic susceptibility targets in Streptococcus pneumoniae, identifying a 'tolerome' that influences resistance and highlights its evolutionary significance.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

This paper designs and evaluates PROTACs that use L3MBTL3 to induce nuclear-specific degradation of FKBP12 and BRD2 by hijacking a methyl reader:E3 ligase complex.

This study examines the microbiota of adults with cystic fibrosis (CF) and finds low diversity and instability in sinus microbial communities, linked to inflammation and worse sinus disease.

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.