K. Zhang

This paper identifies the molecular mechanism of Jin Ning Fang's anti-lung cancer effect using network pharmacology and experimental validation, revealing key targets and compounds involved.

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

The paper shows that stress-induced ubiquitination is essential for recovery of cellular activities following heat stress.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This study investigates the neurobehavioral effects of PCB153 exposure in zebrafish, finding delayed startle responses and disrupted dopaminergic and GABAergic signaling.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

Under constant infection by Sclerotinia sclerotiorum, BnaA03.WRKY28 interacts with BnaA09.VQ12 and takes precedence over phosphorylated BnWRKY33 to bind to the BnWRKY33 promoter, thereby weakening resistance but promoting branching.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This study shows that c-Rel is essential for NK cell cytotoxic function but not for their development, as it regulates perforin and granzyme B expression.

This study investigates the role of HIF-1α in murine responses to Salmonella Typhimurium infection using conditional deletion, finding it dispensable or compensable in immune defense.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study shows that de novo phosphatidylcholine synthesis via CEPT is essential for promastigote survival but not required for amastigote virulence or replication.

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

The paper shows caspases cleave m6A RNA modification components to promote Epstein-Barr virus reactivation.

This study shows that a single dose of spike-functionalized ferritin vaccines in mice generates neutralizing antibodies against SARS-CoV-2, with S{Delta}C-Fer showing higher efficacy than other spike formats.

The paper analyzes transcriptomic responses of cell lines to small molecules, revealing cell type-specific and universal sensitivity patterns with implications for environmental screening.

This study shows that double transmembrane domains in SNAREs slow membrane fusion by increasing protein-lipid mismatch, using in vitro experiments and theoretical analysis.

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

This study shows that C14DM is essential for mitochondrial function and stress tolerance in Leishmania major, leading to increased sensitivity to glucose deprivation and antimicrobial agents.

The paper demonstrates near-atomic resolution structure determination of apoferritin using single-particle cryo-EM with a 300-kV Titan Krios microscope, achieving 1.35 Å resolution and resolving heavy atoms and rotameric configurations.

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.