K. Zhang

The paper investigates how microtubule binding affects LIS1 dissociation from dynein, showing that MT-bound dynein has low LIS1 affinity while MT-unbound dynein binds LIS1 strongly.

This study identifies LOXL2 and its variant L2{Delta}13 as deacetylases that reprogram tumor metabolism by deacetylating aldolase A, promoting tumor progression.

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

The paper investigates L1 retrotransposition in HGSC, finding that despite high L1 mRNA expression, only a third of tumors show somatic insertions, with variability in retrotransposition frequency and patterns.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

This paper designs, fabricates, and characterizes 3D RNA-scaffolded wireframe origami structures using different RNA sequences, revealing structural insights and demonstrating the potential for functional RNA scaffolds.

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

This study investigates how sphingolipids in Leishmania major protect ergosterol from sterol-binding toxins, showing that ceramide reduces toxin cytotoxicity and enhances amphotericin B efficacy.

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.

The paper uses 2DTM to classify 60S ribosome maturation intermediates in yeast cells by analyzing their signal-to-noise ratios in cryo-EM micrographs.

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

The paper presents cryo-EM structures of Chlamydomonas reinhardtii central apparatus and its dynamic conformational behavior, revealing how it regulates ciliary beating.

The paper develops a method to determine high-resolution structures of large microtubule-based motors by removing tubulin-lattice signals from cryo-EM data without requiring microtubule reconstruction.

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

This study determines cryogenic-electron microscopy structures of active and inactive TSHR, revealing how autoantibodies and TSH activate the receptor through similar conformational changes.

This paper introduces a nanopore-based readout method for DNA strand displacement circuits, achieving higher output bandwidth than fluorescence spectroscopy for molecular diagnostics.

The paper explores fusion protein strategies to improve cryo-EM structure determination of GPCRs without signaling proteins, achieving resolutions of 3.4 and 3.7 Å for two receptors.

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study shows that BHMT deletion in mice leads to homocysteine-induced ER stress and CREBH activation, increasing FGF21 which causes adipose browning and atrophy.

This paper introduces As-BDA, a method that detects and quantifies rare mutations down to 0.01% VAF using qPCR, with high concordance compared to ddPCR.