L. Wang

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

The paper uses single-cell RNA-seq to analyze human Wharton’s Jelly-derived MSCs, identifying heterogeneity in gene expression and potential marker genes for potency.

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

This study characterizes the single Shaker K+ channel in Medicago truncatula, MtGORK, and shows its roles in K+ translocation and stomatal control, while demonstrating its dispensability for rhizobial symbiosis.

This study shows diurnal variation in xylem water isotopes biases root water uptake depth estimates and proposes monitoring sap flow and soil water potential to improve accuracy.

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

This study shows Notch3 promotes osteoblastic bone lesions in prostate cancer by inhibiting osteoclasts and enhancing osteoblasts through MMP-3.

This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.

The paper develops a strategy to create fluorogenic probes for live-cell nanoscopy with high cell permeability and low background signal.

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

The paper investigates how binding partners regulate myosin VI activity, showing that Dab2 loss increases nuclear myosin VI activity, promoting estrogen receptor-driven tumourgenesis.

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

This study identifies distinct acylcarnitine metabolomic profiles associated with different subtypes of major depressive disorder following SSRI treatment.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This paper develops a deep learning scheme to classify M. marinum-infected and uninfected macrophages based on morphology, achieving high accuracy at early infection stages.

This paper introduces a novel reporter gene assay for pyrogen detection using NF-κB activation in RAW 264.7 cells, showing sensitivity and applicability to various biological products.

This study investigates how hyperthermia induces neural stem cell differentiation and shows that HSP90 regulates this process through the HIF-1 pathway.

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

This study shows nintedanib reduces vascular remodeling in pulmonary arterial hypertension by inhibiting endothelial mesenchymal transition and smooth muscle cell proliferation.

This study shows capsidiol, a phytoalexin in Nicotiana attenuata, enhances resistance to Alternaria alternata and is regulated by an ERF2-like transcription factor.

This study shows that p62-mediated selective autophagy in virus-transformed cells protects against DNA damage under oxidative stress by regulating CHK1 and RAD51 protein stability.

This study systematically analyzes the distribution of metabolic pathways for five bacterial energy reserves across 8214 proteomes to reveal evolutionary patterns and correlations with genome reduction.

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

This study identifies MIR2052HG's role in regulating LMTK3 and ERα levels, contributing to aromatase inhibitor resistance in breast cancer.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.