M. J. O'Meara

Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans

The paper uses imaging-based screening to identify compounds that inhibit hyphal transition in C. albicans, identifying eIF3 as a target of NSC 697923.

High-Content Screening to Identify Inhibitors of Dengue Virus Replication

This study identifies four nanomolar inhibitors of Dengue Virus replication using high-content screening and a viral pseudotime model.

Human commensal Candida albicans strains demonstrate substantial within-host diversity and retained pathogenic potential

The paper examines genetic and phenotypic diversity in commensal Candida albicans strains from healthy donors and shows they retain pathogenic potential.

In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.

Multiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell

This study identifies multiple ParA/MinD ATPases in bacteria that coordinate the positioning of diverse cellular cargos, revealing specificity determinants and indirect regulatory interactions.

A Human Liver Organoid Screening Platform for DILI Risk Prediction

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

DeORFanizing Candida albicans Genes using Co-Expression

This paper builds a co-expression network for Candida albicans using RNA-seq data to predict gene function and identifies CCJ1 as a novel cell cycle regulator.

The Rosetta all-atom energy function for macromolecular modeling and design

The paper explains the Rosetta all-atom energy function, its mathematical models, and its application to biomolecular modeling and design, including new capabilities for membrane proteins and other macromolecules.