Q. Wang

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

This study demonstrates a 4-fold photoacoustic amplification in silica-coated gold nanoparticles using picosecond laser excitation, attributed to interface heat transfer mechanisms.

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

This paper introduces a microfluidic dielectrophoresis method to rapidly distinguish E. coli with different LPS structures by analyzing electrokinetic properties.

This study identifies DCX and JIP3 as neural-specific regulators that counteract each other in dynein-mediated retrograde trafficking by modulating dynein-microtubule binding and motor complex composition.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

This study shows that PKD promotes prostate cancer bone metastasis by regulating Runx2 via MEK/ERK1/2 signaling, and inhibiting PKD reduces metastasis in mice.

The paper identifies a nonsynonymous SNP in MePOLD1 as the causal mutation for CMD2-type resistance to Cassava Mosaic Geminiviruses, validated through virus-induced gene silencing and allele analysis.

This study identifies key spike protein mutations in SARS-CoV-2 variants that enhance ACE2 receptor utilization across multiple animal species, potentially increasing host range and spillover risk.

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

This study shows that TOPP dephosphorylates ATG13a to promote autophagy in Arabidopsis by facilitating ATG1a-ATG13a complex formation during fixed-carbon starvation.

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

This study shows that modulating STAT1 signaling in chemotherapy-primed breast cancer enhances anti-PD-1 immunotherapy efficacy by altering myeloid cell dynamics.

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

This study identifies key genes regulating mesophyll conductance in drought-resistant rice under severe drought by comparing gene expression and photosynthetic processes between two rice cultivars.

This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

This paper develops a conjugative plasmid model with an attTn7 site for efficient genetic modification to study horizontal gene transfer.

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

The paper reports LTL measurements in 474,074 UK Biobank participants, identifying factors like age, sex, ethnicity, and white cell count associated with LTL variation.