S. Lee

The paper introduces ELIE, a solid-state instrument for detecting amino acids and informational polymers to search for life on icy moons, demonstrating single-molecule detection of L-proline.

The paper improves NMR structure calculation by incorporating hydrogen bond restraints and using ANSURR validation, resulting in more accurate SH2 domain structures.

This study shows that low-level atrazine exposure in mice impairs oocyte quality and worsens age-related aneuploidy, with effects lasting long after exposure ends.

This study identifies AOA-infecting viruses in nitrifying soils and shows their potential to influence host physiology through metabolic gene transfer.

The paper quantifies the contributions of triceps surae and Achilles tendon to ankle impedance during postural control and finds that tendon stiffness dominates above low loads.

This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.

The paper shows that the inner nuclear membrane's lipid environment protects Sun2 from degradation by sensing diacylglycerol through an amphipathic helix, regulated by CTDNEP1 and lipin 1.

This study shows that pancreatic delta cells regulate the glycemic set point in mice by modulating beta cell insulin response through paracrine signaling.

The paper examines how a range-expanding oak gall wasp interacts with parasitoid wasps in its native and expanded ranges, finding reduced apparent competition due to phenological divergence of enemy assemblages.

This study identifies and characterizes ARG2, a gene conferring resistance to anthracnose disease in sorghum, showing its role in defense responses and growth advantages.

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

This paper introduces a method for high-fidelity optical diffraction tomography using non-toxic RI matching media to improve 3D refractive index reconstruction of live organisms.

DINAVID provides a cloud-based system for remote 3D microscopy image analysis and visualization, designed to handle large datasets and improve accessibility.

The paper identifies trogocytic-molting as a process where T cells release TCRs via microvilli, leading to increased surface TCRs and metabolic reprogramming to support clonal expansion.

This study identifies Pi23226, a Phytophthora effector that targets host ribosome biogenesis, inducing nucleolar stress and cell death to promote pathogenicity.

This paper develops a method to sort T cells based on cytokine secretion and surface markers using hydrogel nanovials, finding that polyfunctional cells are more common in CD4+ T cells and remain viable after sorting.

The paper compares chromatin accessibility and active transcription factors between invasive lobular and ductal breast carcinomas using ATAC-seq data from TCGA.

This study identifies CRISIS2, an RxLR effector from Phytophthora capsici, which suppresses plant immunity by interacting with PMA and BAK1, leading to cell death and enhanced pathogen virulence.

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

This study shows that human septins form octamer-based filaments that mediate actin-membrane anchoring, as demonstrated through various imaging and biophysical techniques.

This study identifies tomato SDG33 and SDG34 histone methyltransferases that regulate stress tolerance by modifying H3K4 and H3K36 methylation and expression of negative regulators.

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

This paper shows SARS-CoV-2 directly infects human microglia, causing pro-inflammatory activation and apoptosis, which may contribute to neurological issues in COVID-19 patients.

This study develops a technique to simultaneously quantify ankle, muscle, and tendon impedance in humans and validates its reliability.

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

This study uses a two-phase plant-soil feedback experiment to assess how soil biota influence the invasion success of Phragmites australis in North American wetlands.