S. Lee

This study uses AI and enhanced sampling to accelerate protein unfolding simulations by learning high-dimensional reaction coordinates from poor data.

The paper describes the methods and initial release of the Human Reference Atlas-Vasculature Common Coordinate Framework, a comprehensive database of the adult human blood vasculature.

This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.

The paper designs T=4 protein nanocages with tetrahedral, octahedral, and icosahedral symmetries using pseudo-symmetrization of trimeric building blocks, resulting in structures with distinct subunits and interfaces.

TRAIL agonists reduce radiation-induced lung injury and lethality in mice by inhibiting CCl22 and improving pneumonitis, alveolar-wall thickness, and oxygen desaturation.

This study shows that mild SARS-CoV-2 infection causes long-term gut microbiota instability in both humans and mice, with Omicron variant also disrupting microbial communities despite causing milder symptoms.

The paper shows consistent phenological shifts in seven woody plant species in South Korea over a century, with historical patterns accurately predicting recent changes despite extreme weather.

This paper introduces REMIS, a noninvasive method to measure gene expression in the brain using ultrasound and blood tests, and demonstrates its effectiveness in monitoring chemogenetic activity.

The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.

This study examines how TPO/MPL signaling affects HSC function in bone marrow and spleen, finding distinct compensatory mechanisms in splenic niche cells.

This study shows that dysregulated Hoxa1 isoforms in hematopoietic stem and progenitor cells cause myelodysplastic syndromes and provide mouse models for disease progression.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

The paper validates a computational framework for predicting phase distribution in multi-channel tACS using in vivo primate data, showing strong agreement between simulations and measurements.

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

This paper develops enhanced nanopore sensors with a polymer electrolyte system to analyze heterogeneous nanoparticle mixtures at low ionic strength, demonstrating their applicability to various nanoparticle types.

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

This study uses cholesterol nano-patches to show that spatial cholesterol arrangement induces early T cell activation by forming synthetic lipid rafts and reorganizing signaling molecules.

This study shows taurine biosynthesis via ADO enhances NST in inguinal adipose tissue by remodeling chromatin to increase gene transcription for thermogenesis.

This study identifies AVRblb2 as an effector that targets CNGC channels via CaM/CML proteins to suppress PTI in plants.

This study uses nanovials to screen antigen-specific T cells based on affinity and function, identifying a more specific functional TCR repertoire than standard techniques.

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

This study investigates ZIKV-induced neuroinflammation in adult mice, finding that macrophage IL-1β expression and complement activation contribute to neuroinflammatory damage.

This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

This study shows neuronal E93 in Drosophila regulates adult metabolism and circadian rhythms by acting in GABA and MIP neurons, linking metamorphosis to metabolic homeostasis.

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

This paper introduces a low-cost, wireless capillary rheometer for visualizing and measuring rheological properties of complex fluids.

This study uses cryo-EM to analyze wild-type and oncogenic KIT mutants, revealing structural changes and a potential therapeutic target in cancer.