S. Lee

The paper examines how soil pH affects viral community structure at local and global scales, finding that pH significantly influences both prokaryotic and viral communities.

The paper shows that confined cell migration induces heterochromatin formation and alters chromatin accessibility, which affects migration speed and cellular functions.

This study identifies a 3D-specific mechanosensing mechanism in neural stem cells, showing that Egr1 mediates stiffness-dependent lineage commitment in a range more relevant to brain tissue.

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

This study creates a murine model with JAK2V617F in both hematopoietic and vascular cells, showing it mimics human MPN features like disease progression and cardiovascular issues.

This study shows that JAK2V617F mutant megakaryocytes accelerate hematopoietic aging by affecting HSC interactions and vascular niche function in a murine MPN model.

This study identifies SIRT5 as a desuccinylase that regulates LDHA succinylation, promoting prostate cancer metastasis and progression.

The paper develops a scalable method to produce hydrogel microparticles with localized surface chemistry for cell interfacing, achieving high throughput and precise shape and functionalization.

This study shows that co-culturing the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii increases transcription of carbohydrate binding modules and related enzymes, enhancing biomass breakdown and sugar uptake.

This paper optimizes Cas9 for Cryptococcus neoformans to enable efficient gene editing with short homology arms.

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

This study shows that juvenile zebra finches' preference for their father's song during vocal learning predicts the accuracy of their song imitation in adulthood.

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.

This study shows that defective flow-migration coupling due to ALK1 loss causes arteriovenous malformations in HHT, with integrin-YAP/TAZ signaling as a potential therapeutic target.

The paper characterizes the long-term differentiation of SARS-CoV-2-specific CD8+ T cells in convalescent donors, showing coordinated evolution with other immune components over six months.

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

This study shows that UC colonoids have persistent defects in mucus secretion despite reduced GC numbers, suggesting long-term epithelial dysfunction contributes to UC recurrence.

This paper identifies a hamster model, Phodopus roborovskii SH101, that exhibits systemic SARS-CoV-2 infection with clinical symptoms similar to human COVID-19.

This study demonstrates that 3D8 scFv has antiviral activity against oseltamivir-resistant influenza A virus in cell and mouse models.

This study shows BDNF induces local mtIF3 translation in axons, which supports mitochondrial translation and is necessary for axonal growth.

This study identifies an autoregulatory negative feedback loop involving PIF4 and HECs that modulates thermomorphogenesis in Arabidopsis in response to high ambient temperature.

The paper identifies key immune genes and develops a transcriptional deviance score to predict immune checkpoint inhibitor responses in melanoma patients.

This study identifies active host-virus interactions in methane-fueled soil microbial networks by tracing carbon transfer from hosts to viruses.

This paper develops a multiplex immunoassay to measure SARS-CoV-2 antibody responses and finds that severe COVID-19 is associated with higher early antibody levels against S1 and N proteins.