S. Li

This paper introduces UltraPCR, a method that enables high-precision multiplexing by isolating single molecules in partitions, allowing for unambiguous detection of multiple targets.

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

The paper analyzes hydrogenase diversity, abundance, and expression in groundwater samples, finding high diversity and activity, with new groups linked to different metabolic functions.

This study develops a method to express, purify, and insert SARS-CoV-2 M protein into lipid bilayers, characterizing its structural properties using AFM and Cryo-EM.

This study identifies miR-342 as a master regulator of glycolysis in Foxp3+ regulatory T cells, essential for controlling inflammation in the central nervous system.

This study identifies structural changes in P-Rex1 upon activation by PIP3 and inhibition by IP4, revealing how these interactions regulate its GEF activity.

The paper identifies ICE1 as a key regulator linking cold stress and SA signaling to enhance plant immunity against pathogens.

The paper investigates how Rad26 interacts with lesion-arrested Pol II and identifies Elf1's role in enhancing this interaction for transcription-coupled repair.

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.

This paper introduces a hybrid resolution protein model (HyRes) to accurately simulate the coupling between protein secondary structure and liquid-liquid phase separation in intrinsically disordered proteins.

This study shows that microglia secrete Neuraminidase-3 via extracellular vesicles to prune neurons contact-independently, disrupting network connectivity and contributing to neuroinflammatory diseases.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

This review examines the role of CCL2 in microglial activation and neuronal inflammation, linking it to neurodegenerative diseases and discussing therapeutic strategies.

This paper introduces a new 3-D ultrasound imaging technique called FASTER that improves volume rate and usability compared to conventional methods.

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

This study shows that dietary n-3 PUFA improves dry matter intake in transition cows by altering liver gene expression related to taste transduction and modifying rumen microbial composition.

The paper develops a DMS platform to analyze SARS-CoV-2 spike mutations, finding that spike expression, not ACE2 affinity, primarily affects infectivity and evolution.

This study shows that HD mutations cause a dominant negative effect on HTT function by inducing HD-like phenotypes in non-HD cells.

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study identifies signals that activate the whiB7 stress response in mycobacteria, revealing its role in coordinating an adaptive response to alanine starvation.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

This study shows that Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance by regulating the Akt-mTOR pathway.

This paper identifies two proteins, LppA and JspA, that modulate the ExoR-ExoS-ChvI signaling pathway in S. meliloti, essential for EPS-I production and successful symbiosis with legumes.

This study clones and characterizes the GhERF105a gene in upland cotton, showing its role in pigment gland formation and stress response.