S. Zhang

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

The paper introduces a method to detect and analyze i6A-modified RNA with single-base resolution using iodine-mediated oxidation and reverse transcription.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

This study investigates how DIV1 infection in Marsupenaeus japonicus affects intestinal microbiota, metabolomics, and immune response, revealing secondary bacterial infection and metabolic reprogramming.

This study screens seven organophosphorus pesticides across concentrations in planarians to differentiate neurotoxicity from developmental neurotoxicity, finding distinct toxicological profiles and developmental-specific mechanisms.

This study shows that RB dilution during G1 phase controls cell size in mouse liver by linking cell growth to the G1/S transition.

This study shows that transposable element invasion in Drosophila melanogaster leads to molecular adaptation through recurrent insertions into a specific lncRNA under positive selection.

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

This study examines how aridity affects the distribution and community assembly of cyanobacterial morphotypes in drylands, finding that stochastic processes dominate but aridity influences the balance between determinism and stochasticity.

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

This paper identifies a new family of 'Ca. Nanohaloarchaeota' from hypersaline environments, showing they are an intermediate stage in the evolution of symbiosis with Halobacteria.

The paper identifies CD133+ intercellsomes as a mechanism for intercellular communication to compensate for intracellular signal deficits in stress conditions.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

This study identifies PKC as a key driver of tumorigenic transcriptional networks in prostate cancer by showing its role in cell cycle, EMT, and immune checkpoint regulation.

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

This study shows that modulating STAT1 signaling in chemotherapy-primed breast cancer enhances anti-PD-1 immunotherapy efficacy by altering myeloid cell dynamics.

This paper characterizes quantum dots using hyperspectral fluorescence microscopy to enable multiplexed imaging of biomolecules, showing accurate spectral unmixing of quantum dot mixtures.

This study identifies NONO's role in neuroblastoma by showing its RNA binding is essential for forming condensates that regulate pre-mRNA processing and oncogenic gene expression.

This study uses sugarcane mosaic virus to induce gene silencing in maize, showing it can effectively silence endogenous genes and assess the role of JA-Ile metabolism in plant defense.

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.