V. Kumar

Differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy.

This paper investigates how two LMNA mutations, R453W and W514R, affect lamin A structure, epigenetic regulation, and gene expression in muscular dystrophy.

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

Prioritising the eradication of invasive species from island archipelagos with high reinvasion risk

This paper develops a prioritization method for island invasive species eradication that accounts for reinvasion risk, showing it improves conservation outcomes in case studies.

Colon Innervating TRPA1 Positive Nociceptors Influence Mucosal Health In Mice

This study shows that TRPA1+ve nociceptors are essential for maintaining colonic mucus layer integrity and gut health in mice.

A machine vision based frailty index for mice

This paper introduces a machine learning-based visual frailty index (vFI) for mice using video data, achieving high accuracy in predicting frailty scores and enabling scalable aging studies.

Evaluation of Correlation between CD44, Radiotherapy Response and Survival Rate in Patients with Advanced Stage of Head and Neck Squamous Cell Carcinoma (HNSCC)

Efficient Flocking: Metric Versus Topological Interactions

The paper investigates how metric and topological interaction rules affect flocking dynamics in self-propelled particle models, finding that topological interactions are more effective in achieving ordered motion.

Free spermidine evokes superoxide radicals that manifest toxicity

The paper shows that excess free spermidine generates superoxide radicals, causing toxicity in bacteria lacking the SpeG enzyme, while SpeG enables tolerance by neutralizing spermidine.

Oxo-M and 4-PPBP Delivery via Multi-Domain Peptide Hydrogel Toward Tendon Regeneration

This study develops a multi-domain peptide hydrogel for controlled delivery of Oxo-M and 4-PPBP to enhance tendon regeneration in vivo.

Mucin-mimetic action of capsaicin improves high fat diet-induced gut barrier dysfunction in mice colon

This study investigates how capsaicin affects gut barrier function and mucus production in mice, finding that it improves gut barrier integrity and microbial diversity through TRPV1 and mucus-related mechanisms.

Temporal regulation of Pten is essential for retina regeneration in zebrafish

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

Mapping QTLs for phenotypic and morpho-physiological traits related to grain yield under late sown conditions in wheat (Triticum aestivum L.)

This study maps QTLs for grain yield and related traits under normal and late sown conditions in wheat, identifying a major QTL on chromosome 3B associated with heat tolerance.

Towards increased shading potential: a combined phenotypic and genetic analysis of rice shoot architecture

Through screening a rice diversity panel for variation in shoot architecture, we identified traits corresponding to plant shading potential and their genetic constituents.

Possible link between higher transmissibility of B.1.617 and B.1.1.7 variants of SARS-CoV-2 and increased structural stability of its spike protein and hACE2 affinity

This study uses molecular dynamics simulations to compare the structural stability and binding affinity of SARS-CoV-2 Spike-ACE2 complexes from wild-type and two variants, finding increased binding energy and stability in variants B.1.1.7 and B.1.617.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

Cargo crowding, stationary clusters and dynamical reservoirs in axonal transport

This study develops a simulation model of axonal transport in C. elegans touch neurons, showing that stationary vesicle clusters act as dynamic reservoirs that can be regulated to control cargo flux.

Biomechanical control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium

This study identifies a zygotene cilium in zebrafish oocytes that mechanically regulates chromosomal bouquet formation and germ cell morphogenesis, essential for fertility.

Graph Signal Processing on protein residue networks helps in studying its biophysical properties

The paper uses graph signal processing on protein residue networks to model biophysical properties like folding-rate and secondary structure.

Gait-level analysis of mouse open field behavior using deep learning-based pose estimation

This paper develops a deep learning-based method to analyze mouse gait and posture in open field behavior, showing high heritability and identifying ASD-related gait deficits.

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

This study compares T cell responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that asymptomatic individuals have a robust and functional immune response with balanced cytokine production.

Fragile X Premutation rCGG Repeats Impairs Synaptic Growth and Synaptic Transmission at Drosophila larval Neuromuscular Junction

This study shows that fragile X premutation rCGG repeats impair synaptic growth and transmission at Drosophila larval neuromuscular junctions by affecting presynaptic structures.

Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei

This study identifies an F-BAR domain protein, ArF-BAR, in the fungus Ascochyta rabiei that regulates endocytosis and virulence in chickpea plants, with its expression controlled by the transcription factor ArCRZ1.

Glucose clearance and uptake is increased in the SOD1G93A mouse model of amyotrophic lateral sclerosis through an insulin-independent mechanism

This study shows that SOD1G93A mice exhibit increased glucose uptake and altered glucose homeostasis through an insulin-independent mechanism and impaired glucagon signaling in ALS.

The 'C3aR antagonist' SB290157 is a partial C5aR2 agonist

This paper reveals that SB290157, previously thought to be a C3aR antagonist, acts as a partial agonist at C5aR2 and has mixed effects on C3aR signaling.

The melissopalynological investigation in the Eastern Dry Zone of Karnataka, India

This study analyzes honey samples from Karnataka's Eastern Dry Zone to identify floral sources and pollen diversity, revealing seasonal and location-based variations in bee foraging patterns.

Development of RNA-based assay for rapid detection of SARS-CoV-2 in clinical samples

This paper develops a rapid colorimetric assay for detecting SARS-CoV-2 RNA in clinical samples with high sensitivity and specificity.

Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth

The paper shows that aPKC isoforms sustain HH signaling and BCC growth without primary cilia by compensating for ciliary loss in advanced cancers.

In silico and In vitro evaluation of the anti-inflammatory and antioxidant potential of Cymbopogon citratus from North-western Himalayas

This study evaluates the anti-inflammatory and antioxidant potential of Cymbopogon citratus essential oil using in silico and in vitro methods, showing significant activity compared to standard drugs.

Shoot and root thermomorphogenesis are linked by a developmental trade-off

The paper shows that shoot and root growth responses to high temperature are coordinated during early seedling development through shared signaling modules and auxin regulation.