W. Zhang

This study identifies amino acid residues in HIV-2 capsid protein critical for virus particle assembly by analyzing mutagenesis effects on assembly efficiency and morphology.

This study compares phenotypic and transcriptomic responses of sun- and shade-loving plants to sunlight and dim-light conditions, finding that shade-loving ginseng shows lower phenotypic plasticity but higher photosynthetic efficiency under dim light.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

This study evaluates the anti-tumor activities of 25 sulfonylurea derivatives in breast carcinoma cell lines, finding concentration- and time-dependent inhibitory effects on cell growth, proliferation, migration, and survival.

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

The paper presents a cryo-EM structure of prion fibrils from RML prion-infected mice, revealing structural features and conformational variations that may influence prion strain diversity and propagation.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

The paper quantifies vesicle tethering during plant secretion and shows actin and myosin XI are required for this process, while microtubules have a minor effect.

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

This study improves watermelon transformation efficiency using AtGRF5 and Agrobacterium GV3101, achieving 25% efficiency and enabling CRISPR/Cas9-based knockout mutants.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

This study identifies fluoxetine as a potential therapy for glioblastoma by inhibiting SMPD1 and enhancing temozolomide efficacy, with real-world evidence suggesting improved survival.

This study shows that GATA2 haploinsufficiency in zebrafish leads to epigenetic feedback increasing Gata2b expression, causing myeloid and erythroid dysplasia through lineage differentiation defects.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

The paper examines sex differences in avian parental care across species, finding that care roles vary and are influenced by factors like sexual selection and paternity certainty.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This study shows macaque monkeys use strategy-based hierarchical decision-making to play Pac-Man with over 90% accuracy, revealing advanced cognitive capabilities previously unobserved in animals.

This paper identifies an Alu element insertion in the TBXT gene as the genetic mechanism driving tail-loss evolution in hominoids, showing it causes alternative splicing and tail absence in mice.

The paper investigates DNA repair mechanisms after CRISPR-Cas12a-induced double-strand breaks in Magnaporthe oryzae, identifying locus-dependent and error-prone repair pathways leading to various mutation types.

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

This study shows that inhibiting the IDO1 pathway reduces tumor-infiltrating B cells in melanoma models, suggesting potential therapeutic strategies for solid tumors.