W. Zheng

This study shows that PERK inhibition reduces metastasis by targeting dormant cancer cells through UPR-dependent mechanisms.

The paper uses structural and sequence data to predict responsiveness to pharmacological chaperone treatment for Gaucher disease variants, finding that protein topology and mutation stability influence treatment effectiveness.

The paper develops a TR-FRET assay for SARS-CoV-2 NP detection, enabling high-throughput screening of compounds against SARS-CoV-2 and its variants.

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

The paper shows that CRISPR-Cas13 can reduce RNA in plants without the Cas13 protein, using a mechanism similar to RNAi.

The paper develops a model to capture salt-dependent conformational changes in intrinsically disordered proteins using Forster resonance energy transfer data and experimental LLPS validation.

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

The paper shows that the disordered E-cadherin tail dynamically interacts with β-catenin, achieving specificity and high affinity through transient contacts without dissociation.

This study shows that high transgene expression in Nicotiana benthamiana enables systemic gene silencing, while a partial transposase sequence does not affect this process.

Microbe-seq enables strain-resolved genome reconstruction from complex microbial communities, revealing intra-phylum horizontal gene transfer and bacteriophage-bacterial associations in the human gut.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

This paper develops a high-throughput AlphaLISA assay to detect SARS-CoV-2 nucleocapsid protein, enabling screening of antiviral compounds.

The paper identifies 319 compounds with anti-SARS-CoV-2 activities through a high-throughput screen, including 91 approved drugs and 49 investigational drugs, with 230 compounds previously unreported.

This study examines how SARS-CoV-2 mutations affect protein structures and intraviral interactions, identifying mutations that cause structural changes and alter binding affinity and hot spots.

This study combines proteomics and Mendelian randomization to identify aspirin-targeted proteins associated with reduced colorectal cancer risk.

The paper uses all-atom simulations to study protein condensates, revealing structural and dynamic details of phase separation in two IDPs and showing agreement with experiments.

This study investigates the micro- and macroevolution of Prevotella copri-containing lineage in primate guts, revealing co-evolution with humans, host jumping, and horizontal gene transfer.

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

This study identifies 23 SARS-CoV-2 3CLpro inhibitors through high-throughput screening, with several showing potent activity against viral infection.

This paper develops an in vitro assay to evaluate nucleotide analogs against SARS-CoV-2 RdRp, showing varying incorporation efficiencies and chain termination effects.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

The paper identifies an evolutionary conserved NO-producing system in fungi, mammals, and plants, revealing multifunctional enzymes with implications for agriculture and medicine.

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

This study identifies synergistic and antagonistic drug combinations against SARS-CoV-2 in vitro using in silico prioritization and experimental testing.

This paper explores ATN-161 as a potential therapy for SARS-CoV-2 by targeting the interaction between the spike protein and 5β1 integrin, alongside ACE2.

The paper identifies a cross-subunit interaction in NMDA receptors that stabilizes open states and slows current decay, linking it to pathogenic variants.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.