X. Chen

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This study uses atomic packing frustration analysis to refine predicted protein structures, improving their quality through guided simulations.

This study shows that MFN1-mediated mitochondrial fusion enhances ATP production, which supports autophagy and macrophage mycobactericidal activity against Mtb.

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This paper develops an adaptive optics module for multiphoton imaging in vivo, enabling high-resolution visualization of neural structures and calcium responses in deep brain and spinal cord regions of mice.

This paper develops a 3D reconstruction method using ATUM-SEM and deep learning to analyze hepatic organelle interactions and their morphology.

The paper shows that substrate traits determine microbial community structure in metabolic division of labor by using mathematical models and synthetic consortia experiments.

This study identifies Fascin1 as a regulator of YAP mechanotransduction that promotes cholangiocarcinoma development by sustaining YAP activation in response to ECM cues.

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

The paper shows that cell wall damage disrupts root hair patterning and floral morphogenesis via attenuation of SUB signaling in Arabidopsis.

This study surveys Canadian undergraduate synthetic biology education through iGEM team experiences to provide insights and recommendations for teaching practices.

This paper introduces CeVICA, a cell-free platform for generating SARS-CoV-2 neutralizing antibodies, identifying over 800 binder families and 6 effective inhibitors.

This study shows that combining gemcitabine/cisplatin with CDK4/6 inhibitors improves efficacy and reduces toxicity in biliary tract cancers through mechanisms involving autophagy and RRM1 reduction.

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

This study shows that tuning CAR tonic signaling improves T-cell therapy efficacy by designing CARs with low but non-zero tonic signaling, enhancing anti-tumor activity in mouse models.

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.

The paper identifies four glacier bacteria capable of dual phototrophy using bacteriochlorophyll and rhodopsin, showing genomic evidence of horizontal gene transfer for these systems.

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

The paper reports the cryo-EM structure of Helicobacter pylori urease with a novel inhibitor at 2.0 Å resolution, providing insights for developing high-specificity inhibitors.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.