X. Chen

This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.

This study develops a chemo-mechanical model to explain how RhoA and Rac1 differentially affect endothelial junction dynamics through their roles in contractility, adhesion turnover, and actin polymerization.

This study identifies AcMNPV orf13 as essential for efficient nuclear egress of nucleocapsids during virion budding but not for occlusion body formation.

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

This study shows that HMGB1 is sequestered by plasma sialoglycoproteins at physiological pH but is released during sepsis when pH and zinc levels drop, leading to immune activation.

The paper introduces site-specific phosphorylations in PSD-95 and shows how they affect phase separation with interaction partners, revealing opposing effects on condensate formation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

The paper identifies a novel interaction between BRD8 and the NuA4 complex using chemoproteomics and develops selective probes for BRD8.

The paper identifies safer variants of Staphylococcal protein A (SpA) to develop clinical-grade vaccines for S. aureus, addressing immune escape mechanisms.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

The paper assesses SARS-CoV-2-specific cellular immunity by testing T cell responses to viral antigens and shows varied immune responses and the potential of antigen stimulation to enhance immunity in non-responders.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

The paper identifies hyperactive antibody responses and vascular pathology in metabolic-active lung tissues of tuberculosis patients, sharing features with autoimmune diseases.

This study builds a human walking kinematic model combining lower limb rolling-foot and upper limb multi-rod swinging models, showing good agreement between experimental and theoretical joint velocity calculations.

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

This study identifies how primary tumor-associated macrophages prime disseminating tumor cells for invasion and dormancy, revealing a critical post-extravasation step in metastasis.

This study identifies and characterizes neutralizing antibodies targeting the SARS-CoV-2 spike N-terminal domain, showing their protective efficacy in mice.

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

This paper introduces a preprocessing method to adapt topological data analysis for general stenotic vascular geometries, enabling accurate analysis of vascular disease using persistent homology.

This study uses atomic force microscopy to measure the mechanical properties of breast cancer bone metastases and finds they are more compliant than other cancer models.