X. Dong

The paper reports the assembly of 50S ribosome intermediates using in vitro reconstitution and cryo-EM, revealing parallel assembly pathways and cooperative blocks.

The paper uses cryo-EM and a new segmentation method to reveal the early assembly pathway of bacterial ribosome large subunit, identifying cooperative blocks and a unified maturation landscape.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

This study shows that β1-containing integrins are essential for alveolar repair after injury, as their absence leads to emphysema and impaired differentiation of AT2 cells into mature type 1 alveolar epithelial cells.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

This study isolates and characterizes a novel inovirus, {phi}AFP1, from Alteromonas abrolhosensis, revealing its impact on host metabolism and motility through transcriptomic analysis.

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

The paper identifies minor variant genomes of SARS-CoV-2 early in the pandemic that contain substitutions later found in variants of concern.

This study compares DOPA2 and DSS cross-linkers, finding that faster cross-linking favors the stereospecific complex over encounter complexes in transient protein interactions.

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

This paper develops a bispecific antibody that targets both RBD and S2 of SARS-CoV-2, showing improved neutralization against Omicron and other variants compared to its parental monoclonal antibodies.

The paper examines intraspecies diversity and evolutionary patterns of microbial populations in deep sea cold seep sediments, finding depth-dependent diversification and purifying selection on key metabolic genes.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

The paper introduces TEMP microscopy, a novel tomographic technique for fast volumetric imaging with high resolution and reduced photodamage, demonstrating its effectiveness on scattering tissues and mouse brain slices.

This study examines seasonal changes in litter and soil carbon dynamics in mixed coniferous forests through freeze-thaw experiments, revealing how temperature fluctuations affect carbon release and mass loss.

This study investigates how microbial response strategies vary with environmental change frequency in sulfidic stream microbiomes, finding that rapid changes favor stochasticity and bet-hedging, while slow changes benefit codon-usage bias.

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

This study investigates how Cu(II) and Zn(II) binding affects the structure of the prion protein's octarepeat domain, suggesting a potential role in amyloid formation in TSEs.

This study investigates the role of viruses in wastewater treatment plants, finding they can enhance contaminant degradation but also spread antibiotic resistance.

The paper reports monoclonal antibodies against Plasmodium berghei HAP2 and their crystal structures, showing how they block malaria transmission.

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

This study investigates how the N501Y mutation in the SARS-CoV-2 spike protein's RBD enhances its binding to ACE2, contributing to increased transmissibility of variants.

This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.