X. Li

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

The paper presents a grasshopper genome assembly and finds conservation of X chromosome gene content across insect orders and evidence of recent evolutionary bursts in X-linked genes.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study shows that tumor removal increases prostate cancer cell dissemination to bones, while osteoblasts induce dormancy through focal adhesion kinase inhibition.

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

This study characterizes viral diversity and host interactions in deep-sea hydrothermal vents, revealing novel viral lineages and metabolic roles in host adaptation.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This study shows YAP suppresses AR-driven prostate cancer growth by blocking TEAD-mediated AR signaling through competitive binding.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This study identifies aCcr1, an RHH protein in Sulfolobales and their viruses, which regulates cell cycle progression by modulating gene expression related to division and replication.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study simulates transmembrane potential and electroporation caused by time-varying magnetic fields, showing that nanosecond pulses are more effective than sub-microsecond pulses for membrane electroporation.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This paper reports the genome assembly of Vaccinium darrowii, identifies adaptation traits, and delineates cuticle biosynthesis pathways to aid blueberry breeding.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

The paper identifies RPG as required for infection thread formation in Lotus japonicus and shows it interacts with CERBERUS to mediate polarity growth driven by nuclear migration.

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

This paper develops photoswitchable nanovesicles (azosomes) for precise optical control of molecular release in neurons, demonstrating their ability to activate dopamine receptors in cultured striatal neurons.

This study identifies ATP12A as a potential therapeutic target for idiopathic pulmonary fibrosis by showing its overexpression in IPF lungs and its role in worsening fibrosis in mice.

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.