X. Shi

TCGADEPMAP maps translational tumor dependencies and synthetic lethality using TCGA data, identifying novel targets like PAPSS1/2 with clinical implications.

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

The study shows that a C-terminal fragment of PC1 suppresses cystic disease in a murine model by interacting with a mitochondrial enzyme, affecting metabolism and mitochondrial function.

This study shows that PRC2 heterogeneity in SHH medulloblastomas drives tumor growth through intrinsic and non-cell autonomous mechanisms involving IGF2.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study identifies SCARECROW's role in maintaining telomere integrity and genome stability in Arabidopsis root stem cells through regulation of TEN1 and related factors.

The paper uses CRISPR screening to identify gene-by-gene and gene-by-environment interactions among mitochondrial transporters, revealing SLC25A39's role in mitochondrial glutathione transport.

This paper introduces IMPa, a broad-specificity O-glycoprotease that efficiently cleaves glycoproteins with sialylated and asialylated O-glycans, enabling improved O-glycoproteomics analysis.

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

The paper identifies the EP300 KIX domain as a critical driver of SCLC and shows that targeting this domain can inhibit tumor growth.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

The paper identifies the DISCO complex, essential for ciliogenesis, and shows its role in distal appendage formation and centriole length regulation, linking defects to human ciliopathies.

This study investigates how different cargo receptors stimulate LC3 lipidation in selective autophagy using GUVs and shows varying requirements for autophagy core complexes.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

This study investigates how HIV-1 Nef's flexible regions interact with its core domain to influence SH3 domain selectivity and identifies few human proteins with similar binding properties.

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

This study shows soluble corn fiber reduces ovalbumin-induced sinonasal inflammation in mice, but this effect is lost in mice on a western diet due to microbiota changes.

This study shows that NAD+ redox imbalance worsens diabetic cardiomyopathy by impairing cardiomyocyte function and suggests NAMPT as a therapeutic target.

The paper uses cryo-ET to determine the 7 Å structure of the AcrAB-TolC efflux pump in Escherichia coli, revealing its activation mechanism through interprotein interactions.

This study shows NDP52 allosterically activates ULK1 complex membrane recruitment via FIP200 coiled-coil conformational changes, essential for xenophagy and mitophagy.

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

This study identifies membraneless protein granules formed by RTK oncoproteins that activate RAS/MAPK signaling independently of lipid membranes in cancer.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.