X. Su

This study shows that lipocalin 2 promotes inflammatory breast cancer aggressiveness and skin invasion by enhancing proliferation, migration, and metastasis.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

The paper constructs a global microbiome transition network showing microbiomes are closely connected despite habitat differences, with a scale-free structure and a roadmap of dispersal.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

This study shows CAR T cells bypass LAT for some signaling outputs but still require it for IL-2 production, revealing a rewired signaling pathway.

This study shows PLCγ1 promotes phase separation of LAT in T cell signaling by crosslinking it and protecting it from dephosphorylation, enhancing ERK and SLP76 activation.

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

The paper uses metabolomics to identify heat stress-associated metabolites in corals, finding dipeptides that may serve as diagnostic markers for thermal stress.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

The paper designs and analyzes ACE2-derived peptides to inhibit SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics simulations.

This paper introduces a modular microscale granuloma model to study immune-microenvironment signaling in vitro, showing increased secretion of proinflammatory factors and 3D aggregate formation upon mycobacterial infection.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

The paper uses computational simulations to study the binding dynamics between human ACE2 and the SARS-CoV-2 spike protein's RBD, revealing critical residues and binding modes.

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

This study shows plasmin cleaves ENaC channels at multiple sites, enhancing fluid clearance in lung injury models.

This study introduces a new scallop strain, Bohai Red, and evaluates its hybridization with A. irradians concentricus, finding hybrids show improved survival, growth, and heat tolerance.

The paper introduces injection molded open microfluidic devices for coculture and microscopy, enabling study of cell interactions in standard cell culture workflows.

This study characterizes the mutational and transcriptomic landscapes of a rare prostate basal cell carcinoma using single-cell sequencing, revealing unique gene expression and regulatory patterns.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

This study uses single-cell RNA sequencing to identify naive B cells associated with better prognosis in human HCC by analyzing a mouse model and mapping to the TCGA database.

This study develops a microscale collagen gel contraction assay to investigate fibroblast-induced ECM contraction and intercellular communication in asthma-related fibrosis.

The paper resolves the sex-determination system in Ginkgo biloba, identifying XY chromosomes and five potential sex-determination genes originating ~14 million years ago.

The paper investigates how Nck and WASP mediate the movement of LAT condensates across actin networks during T cell activation.

This study examines how food type and Nosema ceranae infection affect the gut microbiota of Apis cerana workers, finding that beebread supports a more stable microbiota and reduces mortality from infection.

This study shows MapZ forms a stable ring in Streptococcus mutans that guides FtsZ treadmilling, controlling cell division.

This paper evaluates rapid injection molding for microfluidic device fabrication in cell-based assays, identifying advantages, limitations, and design recommendations for academic use.

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.