X. Wang

This study evolves Pseudomonas putida under silver ion or nanoparticle stress, finding distinct mutation patterns linked to different cellular targets and suggesting nanoparticle-specific toxicity mechanisms.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

The paper reports an unexpectedly high mutation rate in Thermococcus eurythermalis, challenges the hypothesis of low mutation rates in hyperthermophiles, and links mutation rate to genome size and population dynamics.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study shows tricuspid valves maladapt in a sheep model of heart failure, leading to structural and mechanical changes that may contribute to tricuspid regurgitation.

This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

Emap2sec+ uses deep learning to detect DNA/RNA and protein secondary structures in intermediate-resolution cryo-EM maps, showing improved accuracy over its previous version.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study identifies POR and CYB5R1 as oxidoreductases that generate hydrogen peroxide, driving iron-dependent lipid peroxidation and ferroptosis.

This study shows that Cops8/CSN deficiency in cardiomyocytes leads to necroptosis via the RIPK1-RIPK3 pathway, with Nrf2 and redox stress playing key roles.

This study identifies the Mocln1-calcineurin-TFEB-p62 pathway as mediating cardiac macroautophagy activation due to proteasomal malfunction.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

This study develops a 3-D constitutive model for high-stiffness agarose gels to predict intra-gel stresses in cell-seeded constructs, enabling better mechanobiology analysis.

Microrisk Lab is an online tool for microbial predictive modeling that performs parameter estimation and simulation, showing performance comparable to existing software.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

This study identifies myofibroblasts as the main contributors to atherosclerotic plaques by demonstrating their role in forming collagen fibers, foam cells, and extracellular lipids in vitro.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.