X. Wang

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study identifies the metabolic pathways regulated by c-GMP in tomato seedlings under salt stress, showing its role in enhancing salt tolerance through changes in gene expression and metabolic profiles.

This study investigates how SMC complexes interact when encountering each other on DNA, showing they can traverse, leading to chromosome reorganization and bypassing steric barriers.

This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.

The paper develops a triple functional sensing chip that detects L. monocytogenes by analyzing three biomarkers, reducing false positives and detection time to 90 minutes.

This study uses single-cell RNA sequencing to identify silkworm hemocyte subsets and analyze their response to BmNPV infection, revealing diverse gene expression changes and immune suppression.

This study shows arachidonic acid metabolism regulates macrophage polarization by affecting oxidative phosphorylation through PPARG, influencing M1 and M2 macrophage activation.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study shows that LRG1 promotes tumor vascular dysfunction and suppresses immunotherapy effectiveness, with its inhibition enhancing therapeutic outcomes in mouse cancer models.

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

This study shows HP1α crosslinks chromatin to maintain nuclear and mitotic chromosome mechanics, independent of histone methylation.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

This paper develops a LAMP assay for rapid detection of the nirS gene in denitrifying bacteria, showing high specificity and sensitivity compared to conventional PCR.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

The paper investigates how an unexpected disulfide bridge in an engineered antibody affects its stability, structure, and dynamics through mass spectrometry and biophysical techniques.

This study identifies CATP-8 as an ER-localized P5A ATPase that removes mislocalized mitochondrial proteins from the ER, preserving ER identity and function.

This paper shows that HPV16 E2 represses TWIST1 transcription, which may explain the better clinical outcomes in HPV16 positive cancers.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

The paper determines cryo-EM structures of bat and pangolin coronavirus spikes, showing PCoV_GX spike binds human ACE2 like SARS-CoV-2, while RaTG13 does not, and identifies key residues and glycans involved in RBD function.

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This study shows that cardiac overexpression of miRNA-7 leads to cardiac dilation instead of adaptive hypertrophy in response to stress, indicating adverse remodeling.