Y. Chen

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

The paper examines ethical issues in disease naming and proposes a method using deep learning to find suitable substitutes for outdated disease names.

This study identifies 315 new RNA viruses in marine invertebrates, revealing hidden diversity and potential host switching events in ocean viromes.

The paper examines the relationship between mangrove forest fragmentation and salt marsh invasion magnitude across a climatic gradient in southeast China.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

This study identifies how the Scribble-E-cadherin complex regulates daughter cell positioning through multiple mechanisms involving spindle orientation and junction formation.

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

This paper shows that Pseudomonas aeruginosa produces novel glycolipids under phosphorus stress, which protect it from polymyxin B antibiotic.

This study identifies Vibrio cholerae in diseased bullfrogs and suggests it can transmit to humans via bullfrog food and aquaculture water, posing a health risk.

This study investigates how the absence of the SP-R210L isoform in macrophages leads to a hyper-inflammatory state through altered genomic and epigenomic responses.

This study identifies and characterizes five cytochrome P450 monooxygenases in switchgrass that catalyze an alternative pathway for furanoditerpenoid biosynthesis, bypassing the canonical class I diterpene synthase pathway.

This study shows bacterial effectors can move between plant cells via plasmodesmata, with movement dependent on molecular weight and regulated by PD proteins and flg22 peptide.

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

This study shows that PKC-θ phosphorylates RanGAP1 to promote its sumoylation and assembly with RanBP2 and Ubc9, facilitating nuclear import of AP-1.

The paper investigates the metapopulation structure of marine bacteria associated with diatoms, finding that closely related bacterial populations are host-specific and show functional differentiation.

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

The paper shows that loss of PABPC1 increases PABPC4 levels and alters key transcriptional regulators in HEK293 cells.

This study identifies Paip2 as a protein that interacts with PABPC1 on mRNA and may help PABPC1 detach from mRNA during deadenylation.

The paper shows PABPC1 is essential for P-body formation despite not being present in P-bodies, and demonstrates GW182's role in mediating this process.