Y. Han

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

This study presents EM structures of the human mitochondrial calcium uniporter holocomplex with and without Ca2+, showing how Ca2+ affects its assembly and channel pore blockage.

This study identifies proteomic changes in mouse hearts after paraquat exposure, showing mitochondrial dysfunction and antioxidant activation, with limited overlap with lung responses.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This study shows that mesenchymal stem cells can deliver oncolytic virotherapy to DIPG tumors, significantly improving survival when combined with radiotherapy in preclinical models.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

This study uses a mechano-osmotic model and experiments to show gap junctions amplify spatial volume variations in multicellular spheroids due to proliferation-induced solid stress.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This paper develops a biosensor capable of continuously measuring multiple analytes in live animals with high sensitivity and temporal resolution, demonstrating its use for glucose and insulin detection in diabetic rats.

This study determines the structure of hDGAT1 with a substrate, revealing its homodimeric organization and substrate-binding sites.

This study finds no sex differences in emotional contagion between male and female rats using a freezing paradigm.

This paper introduces a method for preparing high-yield monolayer graphene cryo-EM grids that improve resolution and protein density for cryo-EM studies.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

This study examines the relationship between serum kisspeptin levels and male fertility, finding a strong correlation with sperm concentration and a potential threshold to distinguish obstructive from non-obstructive azoospermia.

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

This paper describes the de novo formation of organelles in a cyanobacterium, leading to its transition into a eukaryotic alga, and suggests implications for cancer and evolutionary biology.

This study shows that FADD is critical for intestinal intraepithelial lymphocyte (IEL) development, particularly affecting CD8αα+ TCRγδ+ T cells, and its loss worsens colitis.

This study shows that exogenous calcium ions increase Saccharomyces cerevisiae cell wall thickness and patulin adsorption by enhancing key enzyme activities.

The paper compares genomes and transcriptomes of termites and cockroaches to identify molecular mechanisms underlying termite eusociality, finding parallels and differences with Hymenoptera.

The paper demonstrates an in vivo platform using promiscuous terpene synthases and prenyltransferases to generate diverse terpenoids, including novel ring systems.