Y. Lee

The paper identifies phospho-sites in huntingtin, showing PKA phosphorylation of Ser2550 in the C-HEAT domain accelerates its degradation.

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

The paper identifies activators of UCP1 using membrane protein thermostability shift analysis, finding ibuprofen as a novel activator with potential therapeutic implications.

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

The paper determines the structure of an Mrp antiporter using cryo-EM and simulates its mechanism, revealing a histidine-switch critical for ion translocation.

This study identifies MSD2, an apoplastic Mn-SOD in Arabidopsis, showing it modulates ROS distribution in roots during skotomorphogenic growth.

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

This study shows that exhausted mature dendritic cells (xmDCs) move more slowly and less persistently than active matured DCs and immature DCs, but retain CCR7-dependent chemotaxis to CCL19.

This study determines the solution structure of SARS-CoV-2 nsp7 at pH 7.0 using NMR spectroscopy and identifies pH-dependent structural changes in the protein.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

A co-fractionation mass spectrometry pipeline predicts compositions of cytosolic protein complexes in early rice seed development.

This study shows that daily administration of LuCI, an oral gut coating agent, leads to weight loss and improved insulin sensitivity in a rat model of diet-induced obesity.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

This study identifies Ca2+-mediated higher-order assembly of b0,+AT-rBAT as critical for system b0,+ trafficking and reveals its role in type I cystinuria.

This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.

This study examines the population dynamics between Physarum polycephalum and a red yeast in a spatial ecosystem, revealing an inverse growth relationship and oscillatory dynamics.

This study identifies a redox-dependent mechanism by which AMPK dysregulation leads to metabolic failure in glucose-deprived cancer cells, specifically in xCT-high expressing lines.

This study demonstrates that 3D8 scFv has antiviral activity against oseltamivir-resistant influenza A virus in cell and mouse models.

This study analyzes the effects of seed coat color and seed weight on protein, oil, and fatty acid contents in soybean germplasms, finding significant variations in fatty acids and a trade-off between oleic and linoleic acids.

This study shows that bacterial acetyltransferase effectors directly acetylate RIN4 T166, activating RPM1-dependent immunity in Arabidopsis, and that SOBER1 suppresses this by deacetylating the same residue.

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.

This study identifies IP3R over-activation in adipocytes as a key mechanism linking obesity, inflammation, and insulin resistance, suggesting therapeutic targeting of Ca2+ homeostasis.

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.