Y. Shi

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

This study investigates how feed-borne bacteria affect gut microbiota in farmed juvenile Takifugu obscurus, showing that slower growth is linked to greater microbiota instability and increased feed source influence.

This study develops DNA origami nanomedicine to scavenge ROS and NO in M1 macrophages, converting them to M2 subtype and reducing RA inflammation in mice.

This paper introduces a method to efficiently enrich cancer-related exosomes using DNA-tetrahedron nanoweights, achieving high sensitivity and specificity in clinical samples.

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

The paper identifies a chromosomal inversion in walleye fish that may promote adaptive divergence despite gene flow between lakes.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

This study identifies specific chlorinated residues in RidA that are critical for its chaperone activity under oxidative stress.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.

DEEP-MAP uses deep learning and multi-day microscopy data to predict cell fate dynamics in hPSCs without cell state reporters.

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

This study identifies an IFN-stimulated secretory program in PD-L1-resistant tumors that promotes immune evasion and shows that targeting this program can inhibit tumor growth.

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

The paper compares nucleophilic and electrophilic chemical probes for sulfenic acid, finding nucleophilic probes more efficient and selective for Cys-SOH detection.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study examines how gene flow affects the genomic architecture of local adaptation in six riverine fish species, finding that higher gene flow correlates with more clustered adaptive loci.

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

The paper evaluates clustering methods for microbiome data, identifies scenarios where specific metrics underperform, and proposes a combined metric that improves performance across datasets.

This study identifies a malaria parasite phospholipid flippase, ATP7, as essential for ookinete survival in mosquito midgut epithelium, revealing its role in membrane asymmetry maintenance and transmission.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.