Y. Shi

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

This study examines the cardiac phenotype of MK2-deficient mice, finding altered autonomic regulation, increased metabolic gene expression, reduced mitochondrial Ca2+-sensitivity, and delayed hypertrophic remodeling in response to pressure overload.

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

The paper presents a cryo-EM structure of the yeast THO*Sub2 complex and shows its interaction with the SR-like protein Gbp2, suggesting a role in mRNP maturation.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study shows that honeybee gut microbiota influences olfactory learning, brain neurotransmitter levels, and metabolism, with parallels to human autism-related gene expression.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies the lncRNA PLANE as a regulator of alternative splicing that promotes cancer progression by repressing NCOR2-202 splicing, leading to poor patient outcomes.

This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.

The paper identifies a novel basal NSC population in the subventricular zone that contributes to adult neurogenesis, distinct from apical NSCs in molecular and functional properties.

This study shows that insulin resistance in skeletal muscle protects the heart from dysfunction in diet-induced obesity, despite worsening obesity and metabolic syndrome.

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.

This paper develops a de novo lipid labeling method using a single fluorescent probe to analyze subcellular distribution and trafficking of major lipid species in live cells, revealing new biological functions of lipid metabolic enzymes.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

The paper develops a proteomic strategy to analyze antigen-engaged antibody repertoires, revealing high diversity and specificity of camelid heavy-chain antibodies in binding antigens.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.