Y. Shi

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study identifies ZNF524 as a telomere-binding protein that maintains telomere integrity by supporting TRF2/RAP1 localization and preventing DNA damage and recombination.

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

This study identifies METTL7A and METTL7B as the enzymes responsible for thiol methyltransferase activity in liver microsomes, which methylates clinically relevant drugs.

This paper describes a method for efficiently inserting fluorescent proteins into endogenous genes in mammalian stem cells using NHEJ, reducing the time from transfection to imaging to less than two weeks.

The paper shows metformin reduces high glucose-stimulated ATP secretion, blocking purinergic signaling that causes hepatic insulin resistance and glucose production.

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

The paper investigates phosphohistidine (pHis) pathway regulation in the mouse pancreatic tumor microenvironment using novel antibodies and identifies deregulated pHis signals and potential substrates.

This study develops murine hepatoblastoma models from HepT1 cells that exhibit high-risk features like vascular invasion, metastasis, and circulating tumor cells.

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

This study shows that CMA deficiency in mesenchymal cancers promotes tumor growth via TGFβ signaling and metabolic rewiring.

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

This paper introduces a method to improve signal-to-background ratio in 3D-STED nanoscopy using dynamic phase switching with adaptive optics.

This study shows that skeletal muscle is not required for limb regeneration in axolotls, as Pax7 mutants regenerate limbs with normal patterns and cell composition.

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.