Y. Wang

DrugComb updates its repository and analysis tools to include more comprehensive drug combination and monotherapy data, enhanced algorithms, network modeling, and machine learning models for predicting drug sensitivity and synergy.

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

This paper develops and validates an adaptive spectroscopic vis-OCT method to improve retinal oxygen saturation measurements by removing spectral contaminants, showing accuracy in both ex vivo and human retinal vessels.

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

The paper develops a defined medium (NLDM) for cultivating soil bacteria and profiling exometabolites, showing it supports growth of 53 diverse isolates and enables metabolite tracking via LC-MS/MS.

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

This study identifies an NO-to-H2O2 switch in diabetic coronary vasodilation mediated by miR-21, contributing to microvascular dysfunction.

This study introduces a contraction-reaction-diffusion model that generates circular patterns in embryogenesis by coupling mechanobiological factors with traditional reaction-diffusion equations.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

This study uses solid-state NMR to characterize a 72 kDa tryptophan synthase, overcoming size limitations and providing insights into catalytic residues.

The paper uses ribosomal marker protein profiling to show that isolate substrate preferences are conserved in a synthetic soil community and can be predicted by a weighted-sum model.

This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.

This study uses mathematical models to show that aspirin-induced changes in tumor cell fitness can explain reduced colorectal adenoma incidence in treated patients.

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

This study shows KSHV infection of MSCs drives MEndT to generate hybrid M/E state cells, which are tumorigenic and recapitulate KS features, with vFLIP as a key regulator.

The paper assesses the replicative fitness of SARS-CoV-2 B.1.1.7 variant in human organoid models and finds higher infectious virus production and fitness compared to an ancestral strain.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

This study shows oseltamivir treatment does not improve viral clearance in obese mice and may increase viral genetic diversity and drug resistance.

This study identifies GDF8 as a mediator of liver-muscle crosstalk that contributes to muscle atrophy in liver disease and shows that targeting GDF8 can reverse these effects.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

This study shows activin B promotes liver fibrosis initiation and progression by acting on hepatocytes and hepatic stellate cells, and its neutralization prevents and regresses fibrosis in mice.

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

This study determines the NMR structures of two chitin-binding domains from CjLPMO10A and shows functional differences in their chitin-binding affinities and substrate specificity.

This study shows KSHV resolves the bivalent chromatin of PROX1 to activate its expression, promoting MEndT and tumorigenic features in MSCs.

This study shows that CYP46A1 overexpression improves cognitive function in aged female mice but harms male mice, with sex-specific effects on synaptic function and neurodegeneration markers.

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

This paper presents a method to digitally count enzymatic reactions using hydrogel particle-templated drops, achieving femtomolar detection with standard equipment.

The paper identifies and characterizes five hydroxypyruvate reductase genes in Chlamydomonas, revealing distinct enzymatic activities, subcellular locations, and roles in photorespiration.