Y. Wang

This study identifies NK cell production of amphiregulin in human blood ILCs and links it to HIV-1 pathogenesis through cytokine signaling and immune cell dynamics.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

This study investigates how aging impacts vascular function through perivascular adipose tissue and KV7 channels, identifying QO58 as a novel vasodilator for aging-related hypertension.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

This study compares exendin-4 and its acylated variant exendin-4-C16, showing acylation affects GLP-1R signaling bias, trafficking, and pharmacokinetics.

This study investigates how DNA mispairing affects RecG helicase translocation using AFM, finding that certain mismatches block movement while others do not.

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

This study examines the impact of Gypsy retrotransposon bursts on gene expression in Sonneratia alba under salt stress, finding limited correlation between TE activity and nearby gene expression.

The paper identifies and characterizes sequence motifs and ion selectivity mechanisms in channelrhodopsins from diverse algal and protist species using electrophysiological analysis and genomic data.

This study examines how two populations of estuarine cordgrass show opposite DNA methylation patterns under heat stress, suggesting epigenetic mechanisms may enable rapid adaptation to urban environmental challenges.

This study shows that 3-sialyllactose reduces inflammation and atherosclerosis in mice by modulating transcriptional activity in macrophages.

The paper evaluates digital biomarkers from wearable data to predict Parkinson's disease status and symptom severity using a crowdsourced challenge.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

The paper uses microscopy and force measurement techniques to show how localized actin and myosin forces drive target constriction during phagocytosis, revealing a distinct mechanism from 2D cell motility.

This study finds that quantitative susceptibility mapping (QSM) correlates with cardiovascular risk factors and white matter hyperintensities in HIV-infected and uninfected individuals, suggesting QSM as an early marker of brain microcirculation changes.

This study uses silver-stained micro-CT to quantitatively analyze melanin distribution in zebrafish larvae, enabling detailed whole-body phenotyping of pigment patterns and mutant phenotypes.

This study reveals how silkworms use metal ions and pH gradients to drive the self-assembly of silk fibroin nanofibrils into herringbone-like structures for fiber spinning.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.