Y. Xiao

This study identifies YBX1 deficiency causes mis-splicing in BMSCs, leading to senescence and bone loss, and shows Sciadopitysin can reverse this process.

The paper identifies ATM and KEAP1 as targetable vulnerabilities in solid tumors through a CRISPR metabolic screen revealing their synthetic lethality.

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.

The paper identifies Mebendazole as a small molecule that increases lateral root angle in Arabidopsis by inhibiting CTR1 kinase and activating ethylene signaling.

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

The paper shows that the retrograde signal MEcPP increases VIR3 abundance, reducing target enzymes and altering plastid metabolism and structure under stress.

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

The paper identifies boundary domain genes tsh1 and lg2 that suppress inflorescence leaf growth and promote branching in maize through regulatory networks and gene duplication events.

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

The paper identifies a genetic interaction between GT1 and RA3 in maize, showing their roles in suppressing carpel development and inflorescence branching through an ancient developmental program.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

This study shows that total body irradiation in mice leads to ovarian cysts and granulosa cell tumors, with effects dependent on age and radiation dose.

The paper identifies four novel scorpion venom proteins that inhibit Nav1.8, a sodium channel involved in pain signaling, through proteomic and electrophysiological analyses.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

This study establishes conditions for dynamic nuclear polarization (DNP) assisted MAS NMR to detect proteins in viable mammalian cells at micromolar concentrations.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.