Y. Zhang

This paper identifies bis(monoacylglycero)phosphate as a cofactor for arenavirus fusion, showing it promotes late stages of fusion in both Lassa and Junin viruses.

This study identifies TPC2 as a key regulator of adipocyte differentiation via the cAMP signaling pathway, with calpain as a downstream effector, and links genetic variation to fat distribution.

The paper evaluates digital biomarkers from wearable data to predict Parkinson's disease status and symptom severity using a crowdsourced challenge.

This study identifies TFAM3 as a regulator of shoot meristem maturation in plants, showing that ALOG family proteins form transcriptional condensates to control flowering timing and inflorescence architecture.

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

The paper identifies novel bat coronaviruses, including relatives of SARS-CoV-2, from a region in China, providing insights into their evolutionary origins and geographic distribution.

This study shows cyclodextrins activate mechanosensitive channels by mimicking membrane tension through lipid removal, revealing a universal mechanism for channel activation.

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

This study identifies DPYD as a regulator of hepatic steatosis through in vitro experiments showing its inhibition reduces lipid accumulation and its gain-of-function mutation increases lipid burden.

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

This study develops a 3D airway epithelial ALI model to study coronavirus infection and drug efficacy, finding it mirrors human airway responses and drug effects.

This study shows novel synthetic retinobenzoic acids induce neurite outgrowth in human neuroblastoma cells via RARβ and ERK1/2/mTOR pathways, differing from RA's mechanism.

This study compares gait stability and acceleration characteristics between healthy young and older females using inertial sensors, finding older females exhibit less stability and more variability in trunk and foot movements.

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

This study shows BRAF inhibitors reprogram cancer-associated fibroblasts to promote matrix remodeling and resistance to therapy in melanoma by enhancing β-catenin signaling and POSTN expression.

The paper investigates how phosphatidylinositol lipids, particularly PI(4,5)P2, affect Kir2.2 channel gating by analyzing burst and inter-burst durations in planar lipid bilayers.

This study uses AIE dots for non-invasive NIR-IIb fluorescence hysterography to visualize uterine structures and function in mice without impairing reproductive capacity.

This paper combines continuous granulation with 3D printing to improve dissolution rates and physical properties of a poorly water-soluble drug.

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.