Y. Zhang

The paper examines how naturally occurring mutations in SARS-CoV-2 spike proteins affect cell entry via ACE2 and TMPRSS2, finding that the D614G mutation increases infectivity but remains neutralization-sensitive.

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

This study evaluates nitroxoline's effectiveness against persistent Borrelia burgdorferi in vitro, showing it is as active as cefuroxime and effective in combination therapies.

This study shows that high expression of Numb exon 9-containing isoforms correlates with worse prognosis in breast cancer and promotes progression by reducing integrin surface levels and downstream signaling.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

The paper identifies IRP as a DAMP in rice immunity, showing it activates MAPKs and OsWRKYs to amplify chitin signaling.

The paper uses computational methods to analyze proton transfer pathways during the S1 to S2 transition of the Oxygen Evolving Complex in Photosystem II, identifying the broad channel as the most likely proton exit route.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This paper introduces MaAsLin 2, a method for analyzing multivariable associations in microbial multi-omics data, and applies it to reveal new insights into inflammatory bowel disease.

This paper shows that combining ultrasound with an antibody improves Aβ removal and memory in Alzheimer's mice without causing brain bleeding.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

This study shows that Amot is essential for vascular expansion by transmitting mechanical forces through the integrin adhesome in mice.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study shows that low oxygen levels arrest Babesia duncani schizonts and increase susceptibility to antiparasitic drugs in hamster erythrocytes.

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study shows that TIR signaling is essential for enhancing plant defense during pattern-triggered immunity by activating defense genes and increasing resistance to pathogens.

The paper investigates how chromatin mechanics suppress phase separation in the nucleus and control droplet properties through theory and simulation.

This study characterizes an adaptive mutant of Lassa virus glycoprotein complex that confers resistance to fusion inhibitors and alters viral fusion properties.

This study shows that 15-PGDH inhibition improves hematopoietic and gastrointestinal tissue fitness in aged mice by enhancing regeneration and reducing inflammation.

The paper shows that fructose 1,6-bisphosphate sensed by PKM2 regulates MyoD stability and myogenic differentiation by modulating Huwe1 localization.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

This study identifies JAM2 as a prognostic marker and potential predictor of immunotherapy response in breast cancer using multi-database analysis.

The paper identifies CCK/SK-type neuropeptides in starfish, showing they inhibit feeding-related processes through muscle contraction and retraction.

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.