Y. Zhang

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

This study evaluates immune responses in mice to multi-epitope DNA and protein vaccines against CCHFV, finding that DNA prime-protein boost strategy enhances both cellular and humoral immunity.

This study identifies TMEM16F as a phospholipid scramblase essential for trophoblast fusion and placental development by externalizing phosphatidylserine.

This paper shows UNC-45A is preferentially expressed in epithelial cells and co-localizes with microtubules in interphase cells, independent of actin or myosin.

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.

The paper identifies three sequence motifs in Sen1 that directly interact with Nrd1's CID domain and characterizes these interactions structurally and functionally.

This study uses finite element modeling to show that MitraClip increases leaflet stress and myocardial strain in patients with functional mitral regurgitation and coronary disease, with effects amplified by left ventricular enlargement.

The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.

This study identifies a distinct metabolic and immune phenotype in women with right-sided colon cancer through gene expression analysis of public datasets.

This study uses molecular dynamics simulations to show that Aβ(1-40) monomers form stable dimers through specific inter-peptide interactions, without forming long β-strands typical of fibrils.

The paper shows Tyr1 phosphorylation directs P-TEFb to phosphorylate Ser2 on RNA polymerase II CTD, altering its specificity and expanding CTD modification coding potential.

This study shows that prepubertal gonadectomy leads to sex-specific changes in approach-avoidance behaviors in adult mice, suggesting different hormonal mechanisms underlie similar phenotypes.

This study evaluates the antimicrobial activity of 12 botanical medicines and 3 natural agents against growing and non-growing forms of B. burgdorferi in vitro, identifying some with strong activity against non-growing cells.

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

This study evaluates the efficacy and adverse effects of antibiotics in treating M. abscessus pulmonary disease, finding that four antibiotics correlate with treatment success but are associated with severe side effects.

This study shows that low concentrations of melatonin promote cotton seed germination by enhancing antioxidant enzyme activity, reducing MDA, and modulating plant hormones like ABA and GA3.

The paper uses machine learning to predict rapid relapse of triple-negative breast cancer based on clinical and genomic features.

The paper identifies PBS3 as the enzyme that converts isochorismate to salicylic acid via isochorismate-9-glutamate in plants.

This paper introduces a super-resolution microscope that images whole mammalian cells at ~20 nm 3D resolution, revealing complex cellular structures previously only visible via electron microscopy.

The paper assesses azole-resistant Aspergillus fumigatus prevalence in urban vs. rural soils in the UK, finding higher resistance in urban areas with specific genetic alleles.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

This paper develops and validates a Quantitative Dot Blot (QDB) method for absolute quantification of Her2 in FFPE breast cancer tissues, showing high correlation and diagnostic accuracy comparable to IHC and FISH.

This study identifies and analyzes genes involved in ABA production, catabolism, and transport in peanut leaves under drought stress, showing their coordinated regulation of ABA homeostasis.

This study identifies genes regulating cell death in Staphylococcus aureus through a genome-wide screen, revealing both death-resistant and death-sensitive mutants with implications for virulence and antibiotic persistence.

This study uses single-particle tracking to show that KRas diffusion and trafficking are regulated by nested membrane nanodomains in U2OS cells.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study shows that pressure overload in ApoE-/- mice leads to coronary plaque formation, progression, and myocardial events, mimicking human coronary artery disease.

The paper identifies differentially expressed proteins in tumor-associated vascular endothelial cells of colorectal cancer and links some to angiogenesis and metastasis.

This study determines the crystal structures of Mycobacterium tuberculosis σH-RNAP and σH-RPo to elucidate the structural basis of ECF σ factor-mediated transcription initiation.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.