Z. Yang

This study shows leptin activates PKA via AKAP79/150 to increase KATP channel surface trafficking in β-cells, affecting insulin secretion.

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

This study compares gene expression in oil pathways between yellow and purple nutsedge to identify factors contributing to high oil accumulation in yellow nutsedge tubers.

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

This study uses calorimetry to analyze how rexinoid and coactivator peptide affect the thermal stability of RXR-alpha homodimer.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

The paper describes a correlative imaging protocol to visualize calcium signals and ryanodine receptors at nanoscale resolution in primary cells.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

This paper develops a bioelectric neural interface using implantable electrodes and AI to enable intuitive control of a high-DOF prosthetic hand for amputees.

This paper introduces graph neural networks for predicting NMR chemical shifts, achieving accuracy without feature engineering and enabling efficient predictions for diverse molecular structures.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

The paper introduces COCO-Search18, a dataset of goal-directed eye-movement behavior, and benchmarks models for predicting search fixations using deep learning methods.

This study shows that FER and LRXs regulate the nanoscale organization of FLS2 and BAK1 on the plasma membrane, modulating immune signaling in response to RALF23.

The paper investigates peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes, finding that they label non-specific structures in cardiomyocytes.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This study investigates the rupture dynamics of single giant vesicles on solid surfaces, revealing two distinct recurrent rupture modes depending on surface hydrophilicity.

This paper develops a novel water-soluble photosensitizer, sorbicillinoids, for antimicrobial photodynamic therapy that effectively inactivates Gram-positive bacteria under UV light without significant toxicity.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

The paper uses fusion inhibitors to trap HIV-1 in a pre-hairpin intermediate state and visualizes it via electron tomography, revealing the structure of Env-mediated fusion.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study introduces single-cell entropy (scEntropy) to quantify reprogramming and differentiation dynamics in iPSCs using scRNA-seq data, showing increases during differentiation and decreases during reprogramming.

This paper characterizes MET25 as a genetic marker for lead sensing in Yarrowia lipolytica and evaluates its utility as a counter-selectable marker for methylmercury resistance.

TipQAD quantifies spatiotemporal fluorescence dynamics in tip-growing cells, providing accurate measurements of FP-labeled proteins in cytoplasm and plasma membrane.

This study introduces a dynamic model of chromatin folding using molecular dynamics simulations and shows it can reproduce Hi-C contact matrices and reveal dynamics' impact on chromatin structure.

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.