Z. Yang

This study identifies CycK:CDK13 as a kinase complex that phosphorylates SERINC5 at S360, enhancing Nef-mediated downregulation and counteracting its antiviral activity.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

The paper determines cryoEM structures of vascular KATP channels bound to Mg-nucleotides and reveals a conformational pathway for activation.

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

The paper examines ethical issues in disease naming and proposes a method using deep learning to find suitable substitutes for outdated disease names.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

This study evaluates the impact of phase resolution strategies on phylogenomic analyses under the multispecies coalescent model, finding that random phasing leads to biased parameter estimates.

This paper reports the isolation and identification of Bergeyella zoohelcum from a cat-bite infected child, highlighting challenges in its detection and the importance of advanced techniques.

The paper constructs phylogenetic trees using 8-mer motif sets from genome sequences, finding that CG and TA independent selection patterns reflect different evolutionary states in primates and insects.

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

This study shows that the FER-pectin complex transduces mechanical forces to regulate cortical microtubule reorganization via ROP6 GTPase signaling in Arabidopsis.

This study identifies a malaria parasite phospholipid flippase, ATP7, as essential for ookinete survival in mosquito midgut epithelium, revealing its role in membrane asymmetry maintenance and transmission.

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

This study shows that PKC-θ phosphorylates RanGAP1 to promote its sumoylation and assembly with RanBP2 and Ubc9, facilitating nuclear import of AP-1.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This paper compares deep learning and machine learning approaches for decoding motor intent from nerve signals, finding that deep learning offers better accuracy with large data while machine learning is more efficient with smaller datasets.

This study uses full-likelihood analysis to infer species divergence and introgression in Heliconius butterflies, revealing ancestral gene flow and chromosomal inversion histories.

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

This study attempts to increase crossover frequency in Arabidopsis by targeting a recombination hotspot with CRISPR-dCas9-MTOPVIB but finds no significant change in crossover frequency or pattern.

This study shows that silencing lncRNA NEAT1 suppresses ESCC cell proliferation, migration, and invasion by regulating the miR-1299/MMP2 axis.

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

The paper identifies Olfr109 as an olfactory receptor that detects insulin peptides in pancreatic β cells, modulating glucose metabolism and inflammation.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.