Z. Zhang

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

This paper modifies GROMACS to support CIF format for molecular dynamics simulations, enabling processing of large protein complexes.

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

This study identifies STING's ion channel function as critical for non-canonical autophagy and cell death via vesicle de-acidification.

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

This study identifies UBAP2L's role in assembling functional nuclear pore complexes at the nuclear envelope by facilitating Y-complex formation and interactions with key nucleoporins.

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

This study investigates how multivalent cationic lipid MVL5 and PEG-lipids affect the structure of fluid lipid assemblies, revealing distinct morphologies like discs, rods, and spheres.

The paper determines the high-resolution cryo-EM structure of the human KMN network, revealing its subunit organization and phosphorylation-dependent regulation.

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.

The paper shows that deleting XRN1 activates PKR and kills cancer cells with high interferon expression, suggesting XRN1 as a therapeutic target.

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

This paper demonstrates neuromorphic cytometry for cell counting and size estimation, achieving consistent results with traditional flow cytometry for microparticles and THP-1 cells.

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

This paper develops covalent inhibitors that target the K-Ras(G12D) mutation by crosslinking aspartate-12 in both GDP- and GTP-states, effectively suppressing cancer cell proliferation and tumor growth.

This study identifies a temperature receptor and miRNA pathway that mediates the seasonal morphological transition in Cacopsylla chinensis.

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

This study uses coarse-grained simulations to investigate the conformational dynamics of 30S ribosomal subunit assembly in E. coli, revealing key roles of specific proteins in stabilizing the 16S rRNA structure.

The paper identifies SOFTI, a specific inhibitor of SPY O-fucosyltransferase, through virtual screening and validates its effects on O-fucosylation in Arabidopsis and tomato.

This study reports well-preserved columnar shell ultrastructures in early Cambrian brachiopods, revealing their biomineralization processes and evolutionary significance.