structural biology

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

The paper uses MD simulations and computational methods to determine the direction of conformational coupling in RTK dimers, showing it correlates with receptor activity states.

This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.

This paper identifies two lipid-mediated mechanisms of Tissue Factor self-regulation through structural analysis, revealing conformational changes and their impact on FVII binding.

This study shows that phosphoinositide protonation microstates determine AKT1 membrane binding specificity and how mutations alter this interaction.

The paper identifies a conserved NADase domain, NIR, in bacterial immunity and eukaryotic proteins like human TEP1, linking bacterial defense mechanisms to eukaryotic functions.

The paper identifies an alternatively-spliced form of CHC17 (CHC17-SAS) that compensates for the absence of CHC22 in some vertebrates, enabling GLUT4 trafficking.

This study identifies the structural basis of BRD4 interaction with P-TEFb and shows how BRD4 and AFF4 regulate P-TEFb activity through distinct mechanisms.

This study reveals the structural basis of sulfide production in dissimilatory sulfur metabolism through cryo-EM structures of the DsrMKJOP complex from Archaeoglobus fulgidus.

The paper examines the structure and function of the PelBC export complex in Pseudomonas aeruginosa, showing how it stabilizes outer membrane lipids and guides polysaccharide export.

This paper reports cryo-EM structures of EMO and EMO-ETF complex from Syntrophus aciditrophicus, revealing a twin-heme-mediated reverse redox-loop mechanism for methanogenesis from fatty acids.

This study characterizes EpRALPH11, a pea powdery mildew RALPH effector, showing its RNase activity and how its N-terminal region suppresses cell death induction.

This paper characterizes FG214, a heme-binding one-component switch from Fimbriimonas ginsengisoli, showing heme redox state controls monomer-dimer transitions and DNA binding.

The paper reports structures and binding data showing how a sperm protein recognizes divergent egg coat components through conserved interaction geometry and asymmetric binding dynamics.

This paper identifies separate metal-binding sites in Pol γ that regulate its DNA synthesis and strand displacement activities, revealing structural and biochemical mechanisms for mitochondrial DNA replication.

This study identifies VDAC2 as a regulator of BAX activation by stabilizing a primed, membrane-inserted intermediate in the BAX activation pathway.

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

The paper uses structural modeling to identify modular domains in rhizobial effectors that function as transcriptional and post-transcriptional regulators, revealing conserved mechanisms in plant pathogens.

The paper investigates how the Kozak sequence is recognized during eukaryotic translation initiation using cryo-EM structures, revealing an induced-fit mechanism involving conformational changes in mRNA, rRNA, and initiation factors.

The paper investigates how competing factors in biomolecular condensates modulate the rate of poly(A) RNA deadenylation by CNOT7, revealing concentration-dependent increases and diffusion-related decreases in enzymatic efficiency.

This study identifies a conserved dimerization mechanism in SF1A UvrD-family helicases, showing that the 2B domain mediates dimerization and activation across multiple species.

This study shows that CLIMP-63's luminal domain forms flexible trimers and its cytosolic tail mediates clustering, together determining ER sheet width.

The paper investigates dimer asymmetry in blue-light sensor histidine kinases by combining structural and functional analyses to reveal light-dependent conformational changes.

This study identifies a novel protein fold in KSHV ORF24 that enables direct binding to RNAPII CTD, facilitating viral late gene transcription through structural mimicry of a host transcription factor.

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

The paper provides structural evidence for the human Citrate Synthase-Malate Dehydrogenase 2 metabolon and shows its transient nature and non-specific interaction site.

This study shows that micropolymorphisms in HLA-A3 superfamily members affect neoantigen conformational adaptability, influencing TCR recognition.

This paper develops a computational model to simulate HIV-1 capsid rupture during reverse transcription and shows how capsid-DNA interactions drive distinct rupture pathways.