Neuroscience and Neuropharmacology Research

The paper studies short-term plasticity (STP) in the retinocollicular pathway of mice, revealing three distinct stages of STP involving both synaptic and nonsynaptic mechanisms.

This study maps the anatomical organization and origins of VGLUT3-positive axon terminals in the lateral septum, identifying multiple sources beyond the raphe nuclei.

The paper investigates how calcium permeable AMPA receptors in the dorsomedial striatum influence aversion-resistant alcohol drinking through changes in receptor subunit composition and function.

This paper shows that activity-dependent mitochondrial ROS signaling in C. elegans drives avoidance plasticity by enhancing synaptic strength and circuit function.

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

The paper identifies a gene expression program in active neurons that supports sustained network activity, distinct from immediate early gene responses and enriched for excitability regulators.

The paper shows that GABAergic synaptic dynamics form a functional continuum aligned with genetic identities, spanning Pvalb to VIP neurons with Sst as an intermediate class.

This study shows that learning increases spine complexity and formation in adult mice, while reducing spine size, and that spine response discriminability predicts learning performance.

The paper tests if synaptic plasticity depends on the temporal derivative of neural activity, finding LTP for positive derivatives and LTD for negative ones, with no change in stable conditions.

This study shows that spontaneous neurotransmitter release is regulated by the synaptic function of Unc-5 in Drosophila, affecting synaptic structure and behavior.

This study investigates how DLS astrocytes contribute to EtOH-induced stimulation and drinking behavior through calcium signaling and cholinergic interactions in mice.

This study identifies benzothiazole derivatives that modulate PGE2 and GABAergic signaling in skeletal muscle cells, with one compound downregulating Gabrg2, suggesting links between muscle signaling and neuropsychiatric disorders.

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.

This study investigates whether KCNQ-channel openers can restore hippocampal sharp-wave ripples disrupted by glutamate transporter dysfunction in mouse models.

This study shows how two disease-associated GluK2 mutations disrupt different aspects of receptor trafficking and signaling in neurons.

This study investigates the effects of GluD1 deletion on synapse ultrastructure in mice, finding no significant changes in synaptic morphology despite functional deficits.

The paper tracks long-term changes in hippocampal excitatory-to-inhibitory synapses using spike data from mice, finding that covariance of pre- and postsynaptic activity improves prediction of synaptic efficacy fluctuations.

The paper identifies a conserved atomic interaction in inhibitory neurotransmitter receptors that stabilizes channel gating and explains disease-linked mutations.

This study shows that disrupting Slc38a1 in mice leads to cognitive impairments, anxiety, and depressive-like behaviors, linking GABAergic dysfunction to these conditions.

The paper shows that Gi-GPCR signaling in temporal cortex astrocytes enhances fear memory retrieval by modulating Ca2+ transients in response to sensory cues.

The paper identifies molecularly distinct Purkinje cell subtypes and shows they regulate specific behaviors through targeted silencing experiments.

This study shows that brief monocular deprivation induces homeostatic changes in intrinsic neuronal excitability in thalamic relay cells, involving Kv1 and Nav1 channel regulation and electrical coupling.

The paper shows that presynaptic temporal dynamics determine input weights in mouse escape circuit neurons, enabling flexible decision-making during threat.

The paper develops an analytical framework to understand how inhibition affects neuronal computation across dendritic compartments, revealing a unified law that explains inhibitory leverage in active dendrites.

This study shows astrocytes alter the transcriptomic and epigenetic landscape of developing cortical neurons, promoting intrinsic excitability and influencing disease-related pathways.

The paper examines synaptic plasticity in nonhuman primates, finding that theta-burst stimulation induces LTP with a lower threshold for synaptic tagging and capture compared to rodents.

This study shows that postnatal chemogenetic activation of forebrain excitatory neurons leads to anxiety-like behaviors and altered glial function and metabolism in adult mice.

The paper identifies non-random structural motifs in dendrite-soma interactions in cultured hippocampal neurons and shows their association with presynaptic enrichment and strengthening.

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.

The paper identifies ethanol-enhanced presynaptic shunting inhibition at the first central auditory synapse as a mechanism for alcohol-induced auditory dysfunction.