Antimicrobial Resistance in Staphylococcus

High-throughput targeted amplicon screening tool for characterizing intrahost diversity in Staphylococcus aureus directly from sample

This paper develops a low-cost amplicon sequencing assay to rapidly characterize Staphylococcus aureus intrahost diversity directly from samples, enabling transmission analysis without whole-genome sequencing.

Resolving a neonatal intensive care unit outbreak of methicillin-resistant Staphylococcus aureus to the SNV level using Oxford Nanopore simplex reads and HERRO error correction

This paper applies HERRO error correction to Oxford Nanopore sequencing data to resolve a neonatal ICU MRSA outbreak at the SNV level, achieving results comparable to Illumina sequencing.

Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut

This study identifies Staphylococcus haemolyticus as a common gut colonizer in preterm infants and reveals its role as a reservoir of antibiotic resistance genes through genomic analysis.

Whole genome sequence-based characterization of foodborne Staphylococcus aureus isolated from pork in 2018 and 2023.

This study analyzes whole-genome sequences of Staphylococcus aureus isolates from pork in 2018 and 2023, showing increased MRSA prevalence and shifts in dominant clones between Beijing and Copenhagen.

Staphylococcus aureus COL: An Atypical Model Strain of MRSA that Exhibits Slow Growth and Antibiotic Tolerance Due to a Mutation in PRPP Synthetase

Distinct immunity protein families mediate compartment-specificneutralisation of a bacterial toxin

The paper identifies two distinct immunity protein families that neutralize a bacterial toxin from different compartments.

Acquisition of daptomycin resistance in patients results in decreased virulence in Drosophila

This study shows that daptomycin resistance in Staphylococcus aureus reduces its virulence in Drosophila by increasing susceptibility to prophenoloxidase, not through reduced toxin production or immune evasion.

The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics

This study shows that calprotectin reduces β-lactam antibiotic efficacy by inactivating bacterial autolysins through zinc sequestration, independent of bacterial growth.

SSR42 is a Novel Regulator of Cytolytic Activity in Staphylococcus aureus

This paper identifies SSR42 as a novel regulatory RNA in S. aureus that enhances cytotoxicity and virulence by modulating lukAB expression through RNA-RNA interactions.

Trends and characteristics of multidrug resistant MRSA in Norway 2008-2020

This study tracks the rise of multidrug-resistant MRSA in Norway from 2008-2020, showing increasing prevalence and highlighting global spread and healthcare-associated transmission.

Tyrosine availability shapes Staphylococcus aureus nasal colonization and interactions with commensal communities

The paper shows that tyrosine availability influences Staphylococcus aureus nasal colonization and its interactions with commensal bacteria.

Antibacterial activity of tamoxifen derivatives against methicillin-resistant Staphylococcus aureus

This study evaluates the antibacterial activity of 22 tamoxifen derivatives against MRSA, finding three derivatives with dose-dependent growth inhibition and increased membrane permeability.

Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state

This study shows that S. aureus enters a viable but non-culturable state when competing with P. aeruginosa, altering its metabolism and survival strategies in response to antibiotics.

Murine model of antibiotic-associated S. aureus gastrointestinal infections (SAGII) and colonization

This paper develops a murine model of antibiotic-associated S. aureus gastrointestinal infections, showing sexual dimorphism and diet-dependent severity.

Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

The paper identifies mutations in S. aureus USA300 strains that affect gene regulation by combining genetic association testing with transcriptional regulatory network reconstruction.

Characterisation of in vitro resistance selection against second-/last-line antibiotics in methicillin-resistant Staphylococcus aureus

This study evaluates in vitro resistance development in MRSA to vancomycin, daptomycin, and linezolid, identifying mutations and mechanisms associated with resistance.

A mechanistic understanding of the effect of Staphylococcus aureus VraS histidine kinase single point mutation on antibiotic resistance

This study investigates how a single-point mutation in the VraS histidine kinase of S. aureus affects antibiotic resistance through enzyme kinetics, microbiological, and transcriptomic analyses.

Genetic determinants of gene amplifications alter frequency and evolutionary trajectory of antibiotic resistance in Staphylococcus aureus

This study identifies genetic factors that influence gene amplification frequency and evolutionary trajectories to antibiotic resistance in Staphylococcus aureus.

Genome-wide analysis of fitness determinants of Staphylococcus aureus during growth in milk

This study identifies 282 milk-essential genes in Staphylococcus aureus using CRISPRi-seq, highlighting purine biosynthesis, folate cycle, and metal acquisition as critical for growth in milk.

Development of a core genome multilocus sequence typing (cgMLST) scheme and life identification number (LIN) code classification system for Staphylococcus aureus

The paper develops a cgMLST scheme and LIN code system for S. aureus to enable high-resolution genotyping and classification of genetic lineages.

Antimicrobial susceptibility patterns of and biofilm formation by Staphylococcus aureus strains isolated from pediatric patients with atopic dermatitis

This study examines antimicrobial resistance and biofilm formation in Staphylococcus aureus isolates from pediatric atopic dermatitis patients, finding strong associations between biofilm production and disease severity and treatment resistance.

Emergence of ST3390: A non-pigmented HA-MRSA clone with enhanced virulence

This study characterizes the pathogenicity and genomic features of the rare ST3390 MRSA lineage, identifying its hypervirulence and unique genetic traits.

Mitomycin C Retains Efficacy after Adaptive Laboratory Evolution of Staphylococcus aureus

This study shows mitomycin C retains efficacy against Staphylococcus aureus resistance even after adaptive evolution, especially when combined with rifampicin.

The Staphylococcus aureus prophage-encoded SSBP attenuates virulence and enhances IL-6-mediated macrophage clearance

This study identifies a prophage-encoded SSBP that reduces S. aureus virulence and enhances macrophage-mediated bacterial clearance through IL-6 activation.

Global phylogenomic analysis of Staphylococcus pseudintermedius reveals genomic and prophage diversity in multi-drug resistant lineages

This study analyzes global S. pseudintermedius genomes to identify genomic and prophage diversity in multidrug-resistant lineages, showing prophage integration and antiviral systems correlate with disease success.

The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus

This study examines how sub-inhibitory antibiotic concentrations affect mutation rates and persistence in Staphylococcus aureus, showing increased mutation rates and reduced persistence.

Exploring PBP2a resistance in MRSA by comparison between molecular covalent docking and non-covalent docking

This study compares covalent and non-covalent docking methods to analyze PBP2a interactions with beta-lactam antibiotics and understand MRSA resistance mechanisms.

Decoding Host-Pathogen Interactions in Staphylococcus aureus: Insights into Allelic Variation and Antimicrobial Resistance Prediction Using Artificial Intelligence and Machine Learning based approaches

This study uses machine learning to predict antimicrobial resistance in Staphylococcus aureus isolates, identifying key genetic markers and demonstrating high model performance.

Expression of mecA reduces the daptomycin susceptibility of Staphylococcus aureus

This study shows that mecA expression in Staphylococcus aureus reduces daptomycin susceptibility by affecting toxin production and lipid-mediated antibiotic inactivation.

Multi-Omics Analysis of Wound Microbiome and Staphylococcus aureus in Pressure Ulcer

This study uses multi-omics approaches to analyze the wound microbiome and Staphylococcus aureus in pressure ulcers, revealing reduced microbial diversity, antimicrobial resistance, and biofilm formation characteristics.