Developmental Biology and Gene Regulation

This paper reviews the evolution of germ cell specification in Panarthropoda by analyzing historical data and proposing new hypotheses about its developmental trajectory.

This study investigates Notch signaling's role in post-embryonic neurogenesis in Platynereis dumerilii, showing its regulation of progenitor specification, differentiation, and neurogenic balance during regeneration and elongation.

The paper uses genomic mosaicism to study clonal dynamics of trunk neural crest-derived ganglia, finding conserved developmental patterns across species.

This study identifies sumf2 as a key regulator of convergence and extension morphogenesis timing in zebrafish by modulating sulfatase activity and heparan sulfate sulfation.

This study identifies Hox4/5 and Hox6/7 genes' roles in forelimb positioning through loss- and gain-of-function experiments in chick embryos, showing Hox4/5 provide permissive cues and Hox6/7 determine limb position.

The paper studies the transcriptional and cellular maturation of the chick spinal cord at single-cell resolution, revealing similar cell type repertoires for wings and legs and limited transcriptional changes with spatially restricted plasticity in motor neurons.

The paper uses single-cell RNA sequencing to map the transcriptomic changes in the C. elegans Q neuroblast lineage during migration and differentiation, identifying novel genes and Wnt-related mechanisms.

This study compares transcriptomes of cultured and in vivo chicken primordial germ cells using single-cell RNA sequencing, revealing shifts in gene regulatory networks and new intermediate cell states.

The paper shows that the eigengene, the principal component of gene expression, maintains an invariant global spatial pattern across mouse and zebrafish brain development, suggesting evolutionary conservation and a lineage-based explanation.

This study identifies how tissue boundaries guide cell orientation and lumen formation during mouse epiblast maturation.

The paper shows how PAR-3 asymmetry in C. elegans embryos is stabilized by two positive feedback loops involving oligomerization and membrane recruitment.

The paper compares the gene regulatory network of compound eye development between Drosophila and Episyrphus balteatus, finding conserved and species-specific regulatory interactions.

This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.

The paper identifies a collagen expression switch in C. elegans distal tip cells that regulates migration cessation during gonad development.

The paper presents a method to enrich neural crest cells in lizards using antibody labelling and flow cytometry, validated through single-cell RNA sequencing.

This study shows that vesicular glutamate release via VGluT1 is essential for neural tube formation in Xenopus laevis embryos, as its disruption leads to neural tube defects.

The paper uses HCR-FISH to study spatiotemporal dynamics of neural crest gene expression in Xenopus embryos and identifies regulatory relationships between key transcription factors.

This study shows that spiny-ray development in fish is independent of actinotrichia, enabling morphological diversification through osteoblast distribution and signaling molecule intensity.

This paper develops a computational model showing how tissue-wide planar cell polarity can emerge without global morphogen gradients by using local signals and small initial tissue size.

The paper shows directional alignment of cell types helps maintain planar cell polarity in tissues with multiple cell types.

The paper identifies miRNA-mediated regulatory mechanisms that generate left-right neuronal asymmetry in Pristionchus pacificus by rewiring terminal-selector networks.

This study investigates the functional role of clawless in harvestman tarsus development and suggests developmental system drift in arthropod appendage patterning.

This study identifies long Toll receptors as mediators of interface surveillance in Drosophila wing imaginal discs, detecting cell fate aberrations through expression level differences between neighboring cells.

The paper shows that somatic gene silencing in Drosophila germline is essential for maintaining physical segregation from soma, preventing cell death and ensuring germline viability.

This study identifies the thyroid hormone (TH) precursor protein in the ascidian Styela clava, demonstrating endogenous TH synthesis and evolutionary conservation of the TG protein function.

This study shows Bmp9 upregulates Lunatic Fringe in endothelial cells, enhancing Notch signaling and regulating angiogenesis dynamics.

This study identifies NR6A1 as a critical regulator of mammalian neural crest cell specification, formation, and survival through loss-of-function experiments and multiomic analyses.

The paper investigates the role of Notch signaling in ventral mesoderm patterning during early Drosophila embryogenesis and identifies genes regulated by this pathway.