Hearing, Cochlea, Tinnitus, Genetics

Accelerated neural aging as a systems-level vulnerability for tinnitus

This study identifies accelerated neural aging as a risk factor for tinnitus by analyzing MEG and structural imaging data from multiple datasets.

Bone conducted responses using the parallel auditory brainstem response (pABR) paradigm

This study confirms the feasibility of bone conduction pABR by comparing waveforms and thresholds with air conduction in young adults with normal hearing.

Optogenetic circuit mapping reveals connectivity and synaptic physiology of T-stellate projections from the cochlear nucleus to the auditory midbrain

This study maps T-stellate neuron connectivity and synaptic physiology to IC neurons using optogenetics and electrophysiology, revealing differences in input strength and plasticity between NPY and VIP neurons.

A non-invasive test for stria vascularis dysfunction

The paper introduces a non-invasive test to distinguish stria vascularis dysfunction from other causes of hearing loss in mice, using inter-trial coherence in auditory brainstem responses.

Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model

This study differentiates the physiological signatures of cochlear synaptopathy and inner hair cell damage using non-invasive assays in chinchilla models.

Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss

This paper introduces a mouse model of radiosurgery-induced unilateral hearing loss and shows dose-dependent hearing loss and cochlear damage.

A Newly Identified Role of the Tectorial Membrane in Aminoglycoside Ototoxicity

The paper shows that aminoglycosides accumulate in the tectorial membrane, and its structural integrity affects ototoxicity.

Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

The paper investigates age-related hearing loss by inducing cochlear synaptopathy in gerbils and testing auditory perception and neural responses to temporal fine structure.

Estrogen-related receptor gamma is required for normal auditory innervation and is essential for hearing.

This study identifies ESRRG as essential for normal auditory innervation and hearing by showing that its loss causes early-onset hearing loss and synaptic defects in mice.

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's Disease

The paper identifies an auditory brainstem response (ABR) biomarker for Alzheimer's Disease risk in rats, showing genetic risk prediction and intervention effects.

Adenoviral-mediated gene transfer into the scala media of the mouse cochlea in vivo

This study evaluates methods for adenoviral gene delivery to specific inner ear compartments in mice, finding that a cochleostomy approach effectively targets the scala media.

A Regulatory Axis for Tonotopic MYO7A Expression in Cochlear Hair Cells

The paper identifies a cis-regulatory element, EnhancerA, and the transcription factor SIX2 that regulate tonotopic Myo7a isoform expression in cochlear hair cells, linking cochlear position to protein diversity and function.

Cortical inhibitory potentiation reverses maladaptive amygdala plasticity after noise-induced hearing loss

This study shows that enhancing inhibition in the auditory cortex can reverse maladaptive plasticity in the amygdala caused by noise-induced hearing loss.

Entrainment effects and information processing in coupled oscillator models of auditory biomechanics

This study uses coupled oscillator models to show how entrainment and clustering affect information processing in the auditory system, revealing global encoding effects and linking nonlinear dynamics to hearing mechanisms.

Modeling the Influence of Bandwidth and Envelope on Categorical Loudness Scaling

The paper investigates loudness reduction in band-limited noise using a categorical-loudness-scaling paradigm and simulates results with a neural ensemble averaging model.

Multiparametric Classification of Pure-tone Responses Distinguishes Neurons in Inferior Colliculus Subdivisions

The paper uses a random forest classifier to distinguish neurons in two subdivisions of the inferior colliculus based on their response properties to pure tones.

FRMPD4, a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss

The paper identifies FRMPD4 as a causal gene for X-linked non-syndromic hearing loss through genetic analysis and cross-species functional studies.

The RNA editing enzyme ADARB1 is readily detectable in primary auditory neurons and provides a means for automated counting

The paper identifies ADARB1 as a marker for spiral ganglion neurons and validates its use for automated counting across species.

Physiological, Histological, and Cognitive Characterization of a Macaque Model of Presbycusis

This study characterizes age-related hearing loss in rhesus macaques through histological, physiological, and cognitive assessments, finding correlations between auditory deficits and cognitive impairments.

Expression landscape of the genetic hearing loss protein whirlin across human tissues and cell types.

This paper maps the expression of whirlin across human tissues and cell types using multi-omics data, revealing its broad distribution and cell-type-specific patterns.

Dendritic delay lines shape the computation of sound location in neurons of the gerbil medial superior olive

The paper shows dendrites in MSO neurons create internal delays that help neurons detect sound location by adjusting interaural time differences.

Synchronization of two active ears via binaural coupling

This study investigates binaural synchronization in green anole lizards by measuring SOAEs at both ears, finding frequency-dependent phase-locking and showing binaural coupling has greater effects than intra-ear coupling.

Immune response to spiral ganglion neuron death in rats during development and after kanamycin-induced deafening

The paper compares immune responses during developmental spiral ganglion neuron pruning and after kanamycin-induced deafening in rats, finding distinct macrophage and T-cell dynamics in each scenario.

Multi-site MRI analysis of morphometric differences in brain regions in the presence of hearing loss and tinnitus across the adult lifespan

This study examines how hearing loss and tinnitus affect brain structure across the adult lifespan using MRI data, finding specific regional impacts and age-related changes.

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction

This study determines the cryo-EM structure of PCDH15, revealing its right-handed double-helix dimer architecture essential for mechanotransduction.

Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

This study shows MMP-2 and MMP-9 contribute to cisplatin-induced ototoxicity by cleaving RAB proteins, and inhibiting them improves hair cell survival.

Injury-Induced Remodeling of Junctional Actin Bands in the Vestibular Maculae of Mice and Chicks: Implications for Sensory Regeneration

This study compares injury-induced changes in junctional actin bands in the utricles of mice and chicks, finding differences in actin cable thickness and supporting cell expansion that may relate to regenerative capacity.

Cochlear histopathology in macaques after noise-induced temporary threshold shifts

This study examines cochlear histopathology in macaques after noise-induced temporary threshold shifts, finding no significant loss of hair cells or synapses but chronic ribbon enlargement.

Proteomic Remodeling of the Cochlea During Chronic Suppurative Otitis Media Reveals Immune-Driven Injury Pathways

This study identifies immune-driven injury pathways in the cochlea during chronic suppurative otitis media using proteomic profiling in a murine model.

Attention to Speech Modulates Distortion Product Otoacoustic Emissions Evoked by Speech-derived Stimuli in Humans

The paper shows that speech-like distortion product otoacoustic emissions are modulated by selective attention to speech in noise, indicating cochlear active processes contribute to auditory scene analysis.