Hearing, Cochlea, Tinnitus, Genetics

An algorithm underlying directional hearing in fish

The paper introduces a model that quantitatively predicts directional hearing in fish by analyzing phase differences in sound pulses and their effect on startle responses.

Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly(Methyl Methacrylate)-Based Workflow

This paper introduces a rapid rPMMA workflow for molecular histopathology of calcified temporal bones, reducing processing time and costs by 90% while enabling advanced molecular assays.

Differences in Auditory Brainstem Responses between Laboratory-reared and Wild-caught Prairie Voles (Microtus ochrogaster)

The paper compares auditory brainstem responses between laboratory-reared and wild-caught prairie voles, finding differences in thresholds and latency but not amplitude, suggesting environmental influences on hearing.

An Open-Source Deep Learning-Based Toolbox forAutomated Auditory Brainstem Response Analyses (ABRA)

ABRA automates ABR waveform analysis using deep learning, achieving performance comparable to human experts while improving reproducibility and reducing analysis time.

Short tandem repeats significantly contribute to the genetic architecture of metabolic and sensory age-related hearing loss phenotypes

The paper investigates the contribution of short tandem repeats (STRs) to age-related hearing loss phenotypes, finding they explain some missing heritability and identify risk associations.

Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults from the CLSA

The paper identifies distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults using integrated human and mouse data.

Impacts of heminode disruption on auditory processing of noisy sound stimuli

This study models how heminode disruption in spiral ganglion neurons interacts with background noise to impair auditory processing and sound localization.

Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.

This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.

Perceptual and neural biomarkers of distraction from an external sound source are not associated with tinnitus severity

The paper investigates whether neural and behavioral markers of distraction suppression correlate with tinnitus severity, finding no such association.

Active strains in the basal organ of Corti in gerbil

The paper describes strain patterns in the organ of Corti of gerbils using optical coherence tomography, showing how motion varies across regions and frequencies.

Medial Olivocochlear Activity Modulates Central Auditory Synapse Structure and Function

This study examines how altered medial olivocochlear (MOC) activity affects synaptic structure and function in the auditory brainstem using mouse models.

Persistent impairment of spatial hearing and neural binaural interaction after temporary noise-induced hearing loss

The paper shows that temporary noise-induced hearing loss in nonhuman primates leads to long-lasting spatial hearing deficits and reduced binaural neural processing without synapse loss.

Single-Cell Profiling of the Developing Organ of Corti Identifies Etv4/5/1 as Key Regulators of Pillar Cell Identity

The paper identifies Etv4/5/1 as key regulators of inner pillar cell development using single-cell RNA-sequencing and genetic analysis in the developing organ of Corti.

Cadherin-23 Mutations Cause Calcium-Dependent, Allele-Sensitive Mechanosensory Defects

This study shows that mutations in Cadherin-23 affect tip-link function in a calcium-sensitive way, causing hearing loss without impacting balance or vision.

Electrical control of the transduction channels' gating force in sensory hair cells.

The paper shows that electrical potential modulates the gating force of mechanosensitive ion channels in hair cells, affecting mechanosensitivity by altering the gating swing.

Synaptic Input Variation Enhances Rate Coding at the Expense of Temporal Precision in Cochlear Nucleus Neurons

The paper investigates how synaptic input variation in cochlear nucleus neurons affects sound encoding, finding that increased variation enhances rate coding but reduces temporal precision.

EBF1 regulates sensory establishment in the cochlea by positioning the medial boundary of the prosensory domain and restricting proliferation of the sensory progenitor population

The paper uses multiome sequencing to show EBF1 regulates sensory cell development in the cochlea by setting the prosensory domain boundary and limiting progenitor proliferation.

Non-invasive Prenatal MT-RNR1 Pharmacogenetic Testing for the Prevention of Aminoglycoside-Induced Profound Hearing Loss

The paper develops a prenatal pharmacogenetic test using non-invasive prenatal testing data to identify variants in MT-RNR1 that predict risk of aminoglycoside-induced hearing loss with high accuracy.

Inhibitory inputs to avian ITD circuits

The paper investigates inhibitory inputs to the nucleus laminaris (NL) in birds, showing that GABA and glycine contribute to inhibition, with distinct synaptic dynamics and origins from SON neurons.

Optimal parameters for measuring multiband auditory brainstem responses to continuous speech

This paper identifies optimal parameters for measuring multiband auditory brainstem responses using continuous speech, improving testing efficiency and response amplitude.

Impaired development of the medial olivocochlear system in a KCNQ4-deficient mouse model.

This study examines how KCNQ4 deficiency affects the development and organization of cochlear efferent synapses in mice, showing delayed maturation and structural changes in the medial olivocochlear system.

Ultrastructural changes at auditory nerve synapses following moderate noise exposure

This study investigates structural changes in auditory nerve synapses after moderate noise exposure, finding increased presynaptic vesicle density without changes in synaptic contact area or release sites.

Age-Related Changes to Olivocochlear Efferent Neurons in Mice with Pathological Hearing

The paper investigates age-related changes in olivocochlear efferent neurons in mice with different hearing loss conditions, finding differential degeneration patterns in medial and lateral efferent neurons.

Genetic and functional evidence implicates a CRIP3 non-synonymous variant in age-related hearing loss

This study identifies a CRIP3 non-synonymous variant associated with age-related hearing loss and provides genetic, functional, and evolutionary evidence for its role in auditory function.

A Rare Variant in TRIOBP Linked to Occupational Noise Exposure in Meniere Disease

The paper identifies a rare TRIOBP variant associated with Meniere disease in individuals with occupational noise exposure.

An open-source system for recording the auditory brainstem response (ABR) and an example application in mice with hearing loss

The paper describes an open-source, low-cost system for measuring auditory brainstem responses in mice and demonstrates its use in detecting hearing loss.

Ultrastructure of Inputs to the Granule Cell Domain of the Dorsal Cochlear Nucleus

The paper investigates synaptic inputs to the granule cell domain of the dorsal cochlear nucleus, revealing distinct synaptic wiring and chemical signaling for somatosensory integration.

Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

Predicting cochlear synaptopathy in mice with varying degrees of outer hair cell dysfunction using auditory evoked potentials

This study compares ABR, SAM EFR, and RAM EFR to predict cochlear synaptopathy in mice with varying outer hair cell dysfunction, finding RAM EFR best predicts broad synapse loss while ABR best predicts focal synaptopathy.

Spatial hearing and temporal processing ability of the Mongolian gerbil (Meriones unguiculatus) measured using prepulse inhibition of acoustic startle

This study uses prepulse inhibition of acoustic startle to assess spatial hearing and temporal processing in Mongolian gerbils, finding thresholds match those from operant conditioning.